| 王 月,徐冰红,刘 虎,姬朝光,严汉池.溶质转运蛋白超家族的功能及结构研究进展[J].现代生物医学进展英文版,2017,17(24):4775-4783. |
| 溶质转运蛋白超家族的功能及结构研究进展 |
| Research Progress on the Function and Structure of Solute Carrier Superfamily Transporters |
| Received:April 27, 2017 Revised:May 20, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.24.043 |
| 中文关键词: 溶质转运蛋白超家族 功能 疾病 结构 |
| 英文关键词: Solute carriers Function Disease Structure |
| 基金项目:国家重点基础研究发展计划（2013CB910602）；国家高技术研究发展计划（2015AA020101）；天津大学自主创新基金项目（2015XRX-0026） |
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| 中文摘要: |
| 摘要：溶质转运蛋白(solute carriers, SLC)超家族是人类细胞膜（含胞内膜）上最重要的膜转运蛋白家族之一，它参与了细胞间的物质运输、能量传递、营养代谢、信号传导等重要生理活动。SLC转运蛋白超家族包含52个亚家族，共有400多名成员。研究表明，人类基因突变所致SLC蛋白表达异常或功能缺陷与糖尿病、高血压、抑郁症等多种重大疾病密切相关，使得该家族蛋白的功能研究近年来备受关注。SLC转运家族蛋白三维结构的解析有助于阐述其底物选择性结合与转运的精确分子机制，为研究该家族功能相关疾病的分子机理以及针对理性药物研发奠定了精细的三维结构基础。本文对近年来溶质转运蛋白超家族的结构及功能研究进展进行了总结，试图对该家族的共性规律进行阐述。 |
| 英文摘要: |
| ABSTRACT: Solute Carriers(SLC) superfamily is one of the most important membrane transporter families in the cell membrane (including intracellular membrane) of human, it is involved in some essential physiological functions such as intercellular substance transporting, energy transfer, nutrition and metabolism, signal transduction and so on. Solute Carriers(SLC) superfamily contains 52 subfamilies, with more than 400 members. Studies have shown that abnormal protein expression or functional defects of SLC caused by human genetic mutations are closely related with a variety of serious diseases such as diabetes, hypertension and depression, so the function research of SLC had attracted much attention in recent years. The known three-dimensional structures of SLC transporters help to explain the precise molecular mechanism of substrate binding and transporting, it provides a fine structure basis to study the molecular mechanism of related diseases and structure-based drug discovery. In this review, we summarized the progress on the structure and function of SLC superfamily transporters of late years, try to provide some common rules of SLC superfamily transporters. |
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