| 贾海波,严肖啸,任洪波,胡志恒,范振增.亚低温联合穿刺碎吸术治疗高血压脑出血的疗效及对患者血清TNF-α, IL-6, CRP水平的影响[J].现代生物医学进展英文版,2017,17(24):4739-4742. |
| 亚低温联合穿刺碎吸术治疗高血压脑出血的疗效及对患者血清TNF-α, IL-6, CRP水平的影响 |
| Clinical Effect of Mild Hypothermia Combined with Puncture Aspiration Operation on the Hypertensive Intracerebral Hemorrhage and Its Effect on the Serum TNF-α, IL-6 and CRP Levels |
| Received:December 24, 2016 Revised:January 20, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.24.034 |
| 中文关键词: 亚低温 穿刺碎吸术 高血压脑出血 疗效 炎症反应 |
| 英文关键词: Mild hypothermia Puncture aspiration operation Hypertensive intracerebral hemorrhage Clinical effect Inflammatory response |
| 基金项目:河北省自然科学基金项目(06JJ4051) |
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| 中文摘要: |
| 摘要 目的：探讨亚低温联合穿刺碎吸术治疗高血压脑出血的疗效及对患者血清TNF-α、IL-6、CRP水平的影响。方法：选取我院2015年2月~2016年8月收治的112例高血压脑出血患者作为研究对象，采取随机数字表将其分成两组，每组56例。两组患者均给予微创穿刺碎吸术治疗，观察组联合给予亚低温治疗，对比两组手术疗效、并发症、短期预后及手术前后不同时点血清TNF-α、IL-6、CRP水平变化情况。结果：观察组治疗总有效率为92.86%，与对照组(76.79%)相比明显上升(P<0.05)。观察组MODS、总并发症的发生率分别为0%、26.79%，均明显低于对照组(P<0.05)。观察组术后3d、7d血清TNF-α、IL-6、CRP水平逐渐下降，且均明显低于术前(P<0.01)；对照组术后3d血清TNF-α、IL-6、CRP水平与术前相比无明显变化(P>0.05)，术后7d则明显下降，并显著低于术前(P<0.01)；观察组术后3、7d血清TNF-α、IL-6、CRP水平均明显低于同时点对照组(P<0.01)。观察组术后3个月预后良好率为80.36%，与对照组(62.50%)比较明显上升(P<0.05)。结论：亚低温联合穿刺碎吸术治疗高血压脑出血可有效减轻神经功能缺损，抑制体内炎症反应，降低病死率，疗效确切。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of mild hypothermia combined with puncture aspiration operation on the hypertensive intracerebral hemorrhage and its effect on the serum TNF-α, IL-6 and CRP levels. Methods: 112 cases of patients with hypertensive intracerebral hemorrhage admitted in our hospital from February 2015 to August 2016 were selected as the research objectives and randomly divides into 2 groups with 56 cases in each group. Both groups were treated with minimally puncture aspiration, and mild hypothermia was performed in the observation group additionally, the clinical effect, complication, short-term prognosis, serum TNF-α, IL-6, CRP levels at different time points before and after operation were compared between two groups. Results: The overall effective rate of observation group was 92.86%, which was significantly higher than of the control group(76.79%. P<0.05). The incidence of MODS and complications were 0% and 26.79% respectively, which were significantly lower than those of the control group(P<0.05). The serum TNF-α, IL-6, CRP levels of observation group were significantly decreased on the 3rd and 7th day postoperation, which were significantly lower than those before operation(P<0.01). The serum TNF-α, IL-6, CRP levels of control group on the 3rd day postoperation were similar to those before operation(P>0.05), but the serum TNF-α, IL-6, CRP levels on the 7th day postoperation were significantly decreased(P<0.01). The serum TNF-α, IL-6, CRP levels on the 3rd, 7th day postoperation were significantly lower than those of the control group at same time points(P<0.01). The favorable prognosis of observation group was 80.36%, which was significantly higher than that of the control group(62.50%, P<0.05). Conclusion: Mild hypothermia combined with puncture aspiration operation could effectively reduce the neurological deficits, inhibit the inflammatory response and decrease the mortality. |
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