| 方 震,诸靖宇,侯宝生,杨登科,徐 安,沈丽莎,赵 雪,袁 平,杜 广.2型糖尿病患者泌尿系结石形成的相关影响因素分析[J].现代生物医学进展英文版,2017,17(24):4660-4663. |
| 2型糖尿病患者泌尿系结石形成的相关影响因素分析 |
| Analysis of the Related Factors in the Formation of Urinary Calculi in Patients with Type 2 Diabetes Mellitus |
| Received:March 23, 2017 Revised:April 27, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.24.014 |
| 中文关键词: 糖尿病 泌尿系结石 尿酸 |
| 英文关键词: Diabetes Urolithiasis Uric acid |
| 基金项目:浙江省医药卫生科技项目（2017186834） |
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| 中文摘要: |
| 摘要 目的：探讨2 型糖尿病(T2DM)患者泌尿系结石形成的相关影响因素。方法：根据是否合并泌尿系结石，将106例糖尿病患者分为观察组和对照组，每组53例，比较两组患者临床资料及生化指标的差异，并采用多因素回归分析研究2型糖尿病与泌尿系结石的相关关系。结果：观察组和对照组患者的年龄、性别、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、空腹血糖(FBG)、餐后2 h血糖(2hFBG)、糖化血红蛋白(HbA1C)等资料比较差异均无统计学意义(P＞0.05)，而两组患者在体重指数(BMI)、甘油三酯(TG)、尿pH值、胰岛素抵抗指数(HOMA-IR)、血尿酸(SUA)、24小时尿酸(TUA)水平比较差异具具有统计学差异(P＜0.05)，多因素Logistic 回归分析显示血尿酸、尿pH值和HOMA-IR为2型糖尿病患者泌尿系结石形成的重要危险因素(P＜0.05)。结论：高尿酸血症、高甘油三酯血症、高尿酸排泄、胰岛素抵抗、肥胖或超重等因素促进了泌尿系结石的形成，其中血尿酸、尿pH值、HOMA-IR是2型糖尿病患者合并泌尿系结石形成的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the factors and mechanisms in forming uric acid stones in patients with type 2 diabetes(T2DM). Methods: 106 patients with diabetes were divided into observation group and control group according to the combination of urinary calculi, 53 cases in each group, The differences of clinical data and biochemical indexes between the two groups were compared, The relationship between type 2 diabetes mellitus and urinary stones was analyzed by multi factor regression analysis. Results: There were no significant difference in observation group and control group in age, sex, SBP, DBP, TC, FBG, 2hPBG and HbAlC(P＞0.05), and there were of statistical difference significance in BMI, urinary pH, HOMA-IR, SUA, TUA in the two gruops(P＜0.05) and the Logistic regression analysis showed blood uric acid, the urinary pH, HOMA-IR, SUA were independent risk factors in urolithiasis in T2DM(P＜0.05). Conclusion: High uric acid hematic disease, high uric acid excretion, insulin resistance, overweight or obesity, high blood triglycerides in patients with type 2 diabetes is risk factors for urinary stone formation, in which blood uric acid, urinary pH, HOMA-IR is the independent risk factor for type 2 diabetic patients with urinary calculi. |
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