| 程 倬,邓立功,张 莉,杨 帆,朱 蓉.头孢曲松联合雷尼替丁治疗急性胰腺炎患者的临床研究[J].现代生物医学进展英文版,2017,17(23):4560-4563. |
| 头孢曲松联合雷尼替丁治疗急性胰腺炎患者的临床研究 |
| Clinical Observation on Ceftriaxone Combined with Ranitidine in Treatment of Acute Pancreatitis |
| Received:December 30, 2016 Revised:January 28, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.23.038 |
| 中文关键词: 急性胰腺炎 头孢曲松 雷尼替丁 白细胞介素-6 C反应蛋白 临床疗效 |
| 英文关键词: Acute pancreatitis Ceftriaxone Ranitidine Interleukin-6 C-reactive protein Clinical curative effect |
| 基金项目:贵州省自然科学基金项目（09G1036） |
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| 中文摘要: |
| 摘要 目的：探讨头孢曲松联合H2受体阻断剂(雷尼替丁)治疗急性胰腺炎患者的临床疗效及可能机制。方法：92例急性胰腺炎患者按抽签法分为对照组(n=46)与实验组(n=46)，对照组行头孢曲松治疗，实验组基于对照组加用雷尼替丁治疗，比较两组血清白细胞介素-6(IL-6)、C反应蛋白(CRP)、血小板活化因子(PAF)、超氧化物歧化酶(SOD)、丙二醇(MDA)、胃泌素、胃动素、心率(HR)、平均动脉压(MAP)水平的变化，临床表现缓解时间及临床疗效。结果：治疗后，实验组血清IL-6、CRP、PAF、MDA、胃泌素水平及HR均显著低于对照组(P<0.05)，血清SOD、胃动素水平及MAP均明显高于对照组(P<0.05)，临床表现缓解时间明显短于对照组，临床有效率显著高于对照组(P<0.05)。结论：头孢曲松联合雷丁替尼可有效提高急性胰腺炎的临床疗效，可能与其抑制炎症反应、抗氧化作用有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect and mechanisms of ceftriaxone combined with ranitidine on the acute pan- creatitis. Methods: 92 cases of patients with acute pancreatitis were selected and randomly divided into the control group (n=46) and ex- perimental group (n=46), the control group was treated with ceftriaxone, and the experimental group was treated with ranitidine based on the control group, the serum levels of interleukin-6 (IL-6), c-reactive protein(CRP), platelet activating factor (PAF), superoxide dismutase (SOD), propylene glycol (MDA), gastric secrete element, stomach, heart rate (HR), mean arterial pressure (MAP), and the relief time of clinical manifestation and the clinical efficacy were observed and compared between the two groups. Results: After treatment, the serum levels of IL-6, CRP, PAF, MDA, gastric secrete element and HR of experimental group were significantly lower than those of the control group (P<0.05). The serum levels of SOD, stomach motion element and MAP of experimental group were higher than those of the control group (P<0.05). The relief time of clinical manifestation and total efficiency of experimental group were better than those of the control group (P<0.05). Conclusion: Ceftriaxone combined with ranitidine could effectively enhance the clinical efficacy of acute pancreatitis, which might be related to the anti-oxidation and anti-inflammation. |
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