| 陈 波,邱 敏,荣冬靖,王 婷,杨玉琼,保红云,张 扬.乌司他丁对脓毒症急性肾损伤的临床疗效观察[J].现代生物医学进展英文版,2017,17(23):4529-4532. |
| 乌司他丁对脓毒症急性肾损伤的临床疗效观察 |
| Clinical Observation on Efficacy of Ulinastatin in Treatment of Sepsis Induced Acute Renal Injury |
| Received:December 31, 2016 Revised:January 27, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.23.030 |
| 中文关键词: 脓毒症急性肾损伤 乌司他丁 尿损伤分子-1 心钠肽 胱抑素-c |
| 英文关键词: Sepsis acute kidney injury Ulinastatin Urinary injury molecules-1 Atrial natriuretic peptide Cyscatin-c |
| 基金项目:云南省自然科学基金项目(2005J517) |
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| 中文摘要: |
| 摘要 目的：探讨乌司他丁治疗脓毒症急性肾损伤的临床效果及其可能机制。方法：选择我院2014年2月2016年8月收治的114例脓毒症急性肾损伤患者，按抽签法分为对照组(n=57)与实验组(n=57)，对照组采用常规治疗，实验组基于对照组加以乌司他丁治疗，比较两组治疗前后尿液尿损伤分子-1(KIM-1)、心钠肽(ANP)、血清胱抑素-c(CYS-C)、白细胞介素1、6(IL-1、IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、一氧化氮(NO)、内皮素-1(ET-1)、免疫球蛋白A、G、M(IgA、IgG、IgM)、APACHE-Ⅱ评分。结果：治疗后，实验组尿液KIM-1、ANP、血清CYS-C、IL-1、IL-6、CRP、TNF-α、ET-1、APACHE-Ⅱ评分水平均显著低于对照组(P<0.05)，血清NO、IgA、IgG、IgM水平均明显高于对照组(P<0.05)。结论：乌司他丁治疗可显著减轻脓毒症时急性肾损伤，可能与其抑制机体炎症反应，改善肾脏血流灌注，提高免疫功能有关。 |
| 英文摘要: |
| ABSTRACT Objective: To research the clinical effects of ulinastatin in the treatment of sepsis induced acute renal injury and its possible mechanisms. Methods: 114 cases of patients with sepsis induced acute kidney injury from 2014.02 ~ 2016.08 were selected and randomly divided into the control group (n=57) and experimental group (n=57) according to the draw method, the control group was given conventional treatment, while the experimental group was treated by ulinastatin based on the control group, the urine urinary injury molecule-1(KIM-1), atrialnatriuretic peptide (ANP), cyscatin-c (CYS-C), interleukin 1, 6 (IL-1, IL-6), c-reactive protein (CRP), tumor necrosis factor-α(TNF-α), nitric oxide (NO), endothelin 1 (ET-1), immunoglobulin A, G, M (IgA, IgG, IgM) levels, APACHE-Ⅱ score were compared between two groups before and after the treatment. Results: After treatmented, the urine of KIM-1, ANP, serum of CYS-C, IL-1, IL-6, CRP, TNF-α, ET-1 levels and APACHE-Ⅱ score of experimental group were significantly lower than those of the control group(P<0.05). The serum NO, IgA, IgG, IgM levels of experimental group were significantly higher than those of the control group (P<0.05). Conclusion: Ulinastatin could significantly relieve sepsis induced acute renal injury, which might be related to the inhi- bition of inflammatory response, improvement of the renal blood flow and immune function. |
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