| 李天时,郭振丰,其力木格,赵丹丹,李雪连.SERPINE家族在纤维化疾病中作用的研究进展[J].现代生物医学进展英文版,2017,17(22):4391-4393. |
| SERPINE家族在纤维化疾病中作用的研究进展 |
| Research Progress of SERPINE Family in Fibrosis Disease |
| Received:October 12, 2016 Revised:November 10, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.22.046 |
| 中文关键词: 丝氨酸蛋白酶抑制剂E 纤溶酶原激活物抑制剂（PAI-1） 丝氨酸蛋白酶抑制剂（PN-1） 纤维化 |
| 英文关键词: SERPINE Plasminogen activator inhibitor (PAI-1) Serine protease inhibitors (PN-1) Fibrosis |
| 基金项目:黑龙江省自然科学基金项目面上项目（H201402)；黑龙江省博士后科研启动基金（LBH-Q13112) |
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| 中文摘要: |
| 摘要：丝氨酸蛋白酶抑制剂(Serine Protease Inhibitor,Serpin)是一类丝氨酸蛋白酶活性调节剂，在人体中被分为A～I9个亚家族，其中SERPINE(Serpin Peptidase Inhibitor, Clade E)家族参与调节生物体内多个重要的生命过程。本文通过介绍SERPINE家族中两个重要成员SERPINE1与SERPINE2的理化性质、作用机制以及调控因素，阐述SERPINE家族在纤维化相关疾病中的作用及研究进展。 |
| 英文摘要: |
| ABSTRACT: Serine protease inhibitor (serpin) is a kind of serine protease activity regulator，which including nine subfamilies (SERPIN A ~ I). SERPINE (Serpin Peptidase Inhibitor, Clade E) can regulate many important life processes. In this paper, the physical and chemical properties, mechanisms and regulatory factors of SERPINE1 and SERPINE2 in the two important members of SERPINE family are introduced, and the research progress of SERPINE family in the fibrosis related diseases is described. |
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