| 于舒鸿,杨 桐,冯 茜,周 汝,王映梅,张 静.N-cadherin在卵巢癌中的表达及其临床病理意义[J].现代生物医学进展英文版,2017,17(22):4361-4364. |
| N-cadherin在卵巢癌中的表达及其临床病理意义 |
| Expression and Clinicopathological Significance of N-cadherin in the Ovarian Carcinoma |
| Received:March 05, 2017 Revised:March 27, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.22.039 |
| 中文关键词: 第四军医大学西京医院病理科 陕西 西安 710032 |
| 英文关键词: Ovarian carcinoma: N-cadherin Immunohistochemistry Clinicopathological features |
| 基金项目:国家自然科学基金面上项目（81372783，81572545） |
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| 中文摘要: |
| 摘要 目的：探讨N-cadherin在人类卵巢癌组织中的表达及其临床-病理意义。方法：采用免疫组织化学染色法检测281例卵巢癌患者肿瘤组织中N-cadherin的表达，并分析其与患者临床病理特征之间的关系。结果：N-cadherin在卵巢癌原发灶中的表达显著低于配对的转移灶(P=0.018)；卵巢癌组织中N-cadherin的表达与患者FIGO分期(P=0.034)、组织学类型(P<0.001)、肿瘤分级(P=0.004)均显著相关。结论：N-cadherin高表达更多见于进展期(FIGOⅡ-Ⅳ)卵巢癌、高级别浆液性癌及高级别卵巢癌，可能与卵巢癌细胞的侵袭及迁移能力呈正相关，对判断卵巢癌的生物学行为具有重要的参考价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression of N-cadherin and its correlations with the clinicopathological features of human ovarian carcinoma. Methods: The expression of N-cadherin in 281 cases of ovarian carcinoma tissues were determined by immunohistochemical method. The correlations of N-cadherin expression with the clinicopathological features of human ovarian carcinoma were analyzed. Results: There was higher expression of N-cadherin in the metastatic lesions than its paired primary lesions (P = 0.018). The expression level of N-cadherin in ovarian carcinoma was correlated with the FIGO stage (P = 0.034), histological type (P < 0.001) and tumor grade (P = 0.004). Conclusion: High expression of N-cadherin might positively correlate with the invasion and migration ability of ovarian carcinoma cells, which was more common in the the advanced (FIGO II-IV) ovarian carcinoma, high-grade serous carcinoma, and high grade ovarian carcinoma. N-cadherin might be useful in estimating the biological behavior of human ovarian carcinoma. |
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