| 张鲁壮,宋晓洁,崔喜才,祁振国,于 兰.IL-12，IFN-γ，EPO及铁蛋白在急性白血病患者血清中的表达及临床意义[J].现代生物医学进展英文版,2017,17(22):4311-4313. |
| IL-12，IFN-γ，EPO及铁蛋白在急性白血病患者血清中的表达及临床意义 |
| Expression and Clinical Significance of Serum Levels of IL-12, IFN-γ, EPO and Ferritin in Patients with Acute Leukemia |
| Received:March 13, 2017 Revised:March 30, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.22.026 |
| 中文关键词: 急性白血病 IL-12 IFN-γ EPO 铁蛋白 |
| 英文关键词: Acute leukemia IL-12 IFN-γ EPO Ferritin |
| 基金项目:辽宁省科技厅计划项目(2013226012) |
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| 中文摘要: |
| 摘要 目的：研究急性白血病患者血清白介素-12（IL-12）、γ干扰素（IFN-γ）、促红细胞生成素（EPO）、铁蛋白的表达及临床意义。方法：选取2015年8月至2016年7月我院收治的76例急性白血病患者视为观察组，初治组31例，缓解组25例，复发组20例；另选择同期在我院进行健康体检的76例视为对照组。比较急性白血病患者、健康人群及不同疾病阶段的血清IL-12、IFN-γ、EPO、铁蛋白水平。结果：观察组的IL-12、IFN-γ水平显著低于对照组，EPO、铁蛋白水平显著高于对照组，差异均有统计学意义（P<0.05）。初治组、复发组的血清IL-12、IFN-γ显著低于缓解组[（84.21±5.43）pg/mL、（98.7±7.98）pg/mL比（112.43±10.21）pg/mL，（38.54±3.56）pg/mL、（49.87±4.02）pg/mL比（108.32±8.43）pg/mL]（P<0.05），EPO、铁蛋白水平显著高于缓解组[（402.32±42.31）mIU/mL、（321.58±30.21）mIU/mL比（98.21±9.45）mIU/mL，（653.21±54.24）ng/mL、（512.87±43.45）ng/mL比（342.15±25.12）ng/mL]（P<0.05）。结论：急性白血病患者血清IL-12、IFN-γ水平较低，EPO、铁蛋白的表达较高，可通过监测上述指标变化评估病情及预后。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expressions of serum levels of interleukin-12 (IL-12), interferon-γ (IFN-γ), erythropoietin (EPO) and ferritin in patients with acute leukemia and its clinical significance. Methods: 76 patients with acute leukemia who were treated in our hospital from July 2015 to July 2016 were selected as the observation group, including 31 cases of newly diagnosed group, 25 cases of remission group and 20 cases of relapse group. And another 76 cases who had taken the physical examination in our hospital were selected as the control group. Then the levels of serum IL-12, IFN-γ, EPO and ferritin in patients were observed and compared between the two groups. Results: The levels of IL-12 and IFN-γ in the observation group were significantly lower than those of the control group, and the levels of EPO and ferritin were significantly higher than those of the control group (P <0.05). The levels of serum IL-12 and IFN-γ in the untreated group and the relapse group were significantly lower than those of the remission group [(84.21±5.43)pg/mL, (98.7±7.98)pg/mL VS(112.43±10.21) pg/mL, (38.54±3.56)pg/mL, (49.87±4.02)pg/mL VS(108.32±8.43)pg/mL](P <0.05), and the levels of EPO and ferritin were significantly higher than those of the remission group [(402.32±42.31) mIU/mL (321.58±30.21) mIU/mL VS (98.21±9.45) mIU/mLM (653.21±54.24) ng/mLM(512.87±43.45)ng/mL VS(342.15±25.12)ng/mL] (P<0.05). Conclusion: The serum levels of IL-12 and IFN-γ in patients with acute leukemia were lower, and the expression of EPO and ferritin was higher, and the disease and prognosis could be evaluated by monitoring the changes of these indexes. |
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