| 宋 哲,周治军,徐 康,万 涛,卢 童,徐建国.腹腔镜下根治性膀胱切除术治疗膀胱癌的疗效及对患者血清IL-6及IFN-γ水平的影响[J].现代生物医学进展英文版,2017,17(21):4100-4103. |
| 腹腔镜下根治性膀胱切除术治疗膀胱癌的疗效及对患者血清IL-6及IFN-γ水平的影响 |
| Curative Effect of Laparoscopic Radical Cystectomy in Treatment of Bladder Cancer and Serum Levels of IL-6 and IFN-γ |
| Received:January 17, 2017 Revised:February 06, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.21.025 |
| 中文关键词: 膀胱癌 腹腔镜下根治术性膀胱切除术 白细胞介素-6 干扰素-γ |
| 英文关键词: Bladder cancer Laparoscopic radical cystectomy Interleukin-6 Interferon-γ |
| 基金项目:湖北省自然科学基金项目（10J2057） |
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| 中文摘要: |
| 摘要 目的：分析腹腔镜下根治性膀胱切除术治疗膀胱癌的疗效及对血清白细胞介素-6（IL-6）、干扰素-γ（IFN-γ）的影响。方法：将106例膀胱癌患者参照随机数表法分作对照组与实验组，对照组予以开放根治性膀胱切除术，实验组予以腹腔镜下根治性膀胱切除术。观察并比较两组患者术中出血量、肛门排气时间、住院时间、手术时间、淋巴结清扫阳性率，血清IL-6，IFN-γ，P物质，前列腺素E2（PGE2），CD3+，CD4+，CD8+，纤维蛋白原（Fg），活化部分凝血活酶时间（APTT），凝血酶原时间（PT）及并发症的发生率。结果：实验组出血量、肛门排气时间、住院时间少于对照组，但手术时间多于对照组，差异具有统计学意义（P<0.05）；两组淋巴结清扫阳性率、Fg、APTT、PT比较无差异（P>0.05）。实验组IL-6，P物质，PGE2，CD8+均低于对照组，但IFN-γ，CD3+，CD4+及CD4+/CD8+均高于对照组（P<0.05）。实验组并发症率低于对照组（P<0.05）。结论：腹腔镜下根治术膀胱癌切除术治疗膀胱癌的疗效肯定，对血清IL-6及IFN-γ的影响较小，并可抑制疼痛应激指标的分泌，保护机体免疫功能。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the curative effect of laparoscopic radical cystectomy on serum levels of interleukin-6 (IL-6) and the influence of interferon-γ (IFN-γ) of patients with the bladder cancer. Methods: 106 patients with bladder cancer were selected and randomly divided into the control group and the experimental group. The patients in the control group were treated with the open radical cystectomy, while the patients in the experimental group were treated with the laparoscopic radical cystectomy. Then the blood loss, the exhaust time, the hospitalization, the operation time, the positive rate of lymph node cleaning, the serum levels of IL-6, IFN-γ, substance P, prostaglandin E2 (PGE2), CD3+, CD4+, CD8+ and fibrinogen (Fg), the activated partial clotting enzyme live time (APTT), the pro- thrombin time (PT) and the incidence of complications between two groups were observed and compared. Results: The blood loss, the exhaust time and the hospitalization in the experimental group were shorter than those of the control group, while the operation time was longer, and the differences were statistically significant (P<0.05); There was no statistically significant difference about the positive rate of lymph node, Fg, APTT and PT between the two groups (P>0.05); The serum levels of IL-6, substance P, PGE2 and CD8+ of the experi- mental group were lower than those of the control group, while the serum levels of IFN-γ, CD3+, CD4+ and CD4+/CD8+ were higher, and the differences were statistically significant (P<0.05). The incidence of postoperative complications in the experimental group was lower than that of the control group (P<0.05). Conclusion: Laparoscopic radical resection has obvious curative effect on the treatment of blad- der cancer, which can reduce the serum levels of IL-6 and IFN -γ, inhibit the secretion of stress indexes, and protect the immune func- tions of patients. |
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