| 朱兴华,张 逸,蔡玉辉,王 磊,王 冬.烧伤患者血浆IGFBP-1水平的变化及临床意义[J].现代生物医学进展英文版,2017,17(21):4093-4095. |
| 烧伤患者血浆IGFBP-1水平的变化及临床意义 |
| Expression Changes of IGFBP-1 Level in Burn Patient and Its Clinical Significance |
| Received:December 03, 2016 Revised:December 27, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.21.023 |
| 中文关键词: 烧伤 胰岛素样生长因子结合蛋白-1 胰岛素样生长因子 临床意义 |
| 英文关键词: Burn IGFBP-1 IGF-1 Clinical significance |
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| 中文摘要: |
| 摘要 目的：探究烧伤患者血浆胰岛素样生长因子结合蛋白-1（IGFBP-1）水平的变化及其临床意义。方法：选择2013年1月-2015年1月我院收治的70例烧伤患者作为研究组，依据总体表烧伤面积（TBSA）将患者分为4个亚组：Ⅰ组（1%~15%）34例、Ⅱ组（16%~30%）9例、Ⅲ组（31%~50%）17例、Ⅳ组（51%~95%）10例；选取同期于我院体检健康者50例作为对照组。测定研究者IGFBP-1、胰岛素样生长因子（IGF-1）水平，分析其与TBSA的相关性。结果：在10d观察期内，Ⅲ组和Ⅳ组患者的IGF-1水平均显著低于对照组（P＜0.05），而Ⅱ组患者IGF-1水平仅在烧伤后1 d时与对照组存在差异（P＜0.05），且在烧伤后2 d，随着分级的增加，血浆IGF-1水平有下降的趋势，组间差异具有统计学意义（P＜0.05）；研究组患者的IGFBP-1水平均显著高于对照组（P＜0.05）；随着分级的增加，血浆IGFBP-1有上升的趋势，组间差异具有统计学意义（P＜0.05）；线性相关性分析显示，烧伤患者血浆IGF-1水平与TBSA值呈负相关（r=-0.693，P＜0.05）；血浆IGFBP-1水平与TBSA值呈正相关（r=0.377，P＜0.05）。结论：烧伤患者血浆IGF-1水平显著下降，而IGFBP-1水平则显著升高，与烧伤严重程度密切相关，二者可作为判断烧伤患者预后的重要预警指标。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expression changes of insulin-like growth factor binding protein-1 (IGFBP-1) level in burn pa- tient and its clinical significance. Methods: 70 cases of burn patients who treated in our hospital from January 2015 to January 2013 were selected as research group, total burn surface area (TBSA) was divided into 4 subgroups:group I (1%~15%) 34 cases,group II (16%~30%) 9 cases,group III (31%~50%) 17 cases,group IV (51%~95%) 10 cases;In the same period,50 healthy persons were selected as the control group.IGFBP-1 and insulin like growth factor (IGF-1) levels were determined,analyzed of its correlation with TBSA. Results: In the 10d during observation period, the level of IGF-1 in group III and group IV was significantly lower than that in control group (P<0.05), while the IGF-1 levels were significant difference between group Ⅱ and control group at 1d after burn (P<0.05), and in burn 2 d, as the grade of increased, the plasma IGF-1 level has a downward trend, the difference was statistically significant (P<0.05); The levels of IGFBP-1 in the research group were significantly higher than those in the control group (P<0.05); As the grade of increased, the plasma IGFBP-1 level has a upward trend, the difference was statistically significant (P<0.05); Linear correlation analysis showed that the plasma level of IGF-1 was negatively correlated with TBSA value in burn patients (r=-0.693, P<0.05); Plasma IGFBP-1 levels was positively correlated with TBSA (r=0.377, P<0.05). Conclusion: Plasma levels of IGF-1 were significantly decreased in burn patients, while IGFBP-1 levels were significantly increased, which were closely related to the severity of burn, and the two were important indicators of early warning for the prognosis of burn patients. |
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