| 毛婷婷,何进勇,李征征,卫晓慧,袁胜涛.肥胖微环境促进脂肪纤维化的发病机制研究进展[J].现代生物医学进展英文版,2017,17(19):3798-3800. |
| 肥胖微环境促进脂肪纤维化的发病机制研究进展 |
| Pathogenesis Progress of Obesity Environment in Promoting Adipose Tissue Fibrosis |
| Received:January 16, 2017 Revised:February 13, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.19.050 |
| 中文关键词: 纤维化 炎症 缺氧诱导因子 胶原 |
| 英文关键词: Fibrosis Inflammation Hypoxia inducible factor Collagen |
| 基金项目:国家自然科学基金项目(81302794，81573456)；国家高技术研究发展计划（863）（2014AA022208） |
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| 中文摘要: |
| 摘要：现代研究发现脂肪组织的功能不仅仅只是储存以及释放脂类，还作为人体的内分泌腺，在维持机体代谢平衡方面具有重要的作用。而肥胖状态时脂肪组织的分泌功能紊乱，炎症因子与脂肪因子分泌失衡，打破了机体的代谢平衡。更糟糕的是，脂肪组织形成慢性低度炎症以及缺氧微环境，引起胶原的异常沉积，脂肪组织纤维化，从而破坏脂肪组织正常功能，可能进一步导致糖尿病以及肿瘤的产生。因此，本文主要概述肥胖引起的慢性炎症和缺氧微环境通过分泌炎症因子、上调缺氧诱导因子的表达，进而改变脂肪细胞外基质的组成，最终促进脂肪纤维化的发生的机制。 |
| 英文摘要: |
| ABSTRACT: Modern studies reveal that the adipose tissue not only storages and releases lipids but also plays a pivotal role in main- taining the body's metabolic balance, as an endocrine gland. However, the secretion function of adipose tissue is disturbed in obesity. Obesity breaks the balance between inflammatory factor and adipocytokines. As a result, the balance of overall metabolism is broken. What's worse, the imbalance results in chronic inflammation and hypoxia, which promote collagen deposition, adipose tissue fibrosis and dysfunction. Furthermore, fibrosis may initiates diabetes and cancer. Therefore, this review summarizes the mechanism of adipose tissue fibrosis by obesity-induced chronic inflammation and hypoxia microenvironment, mainly through changing the extracellular matrix by se- cretion of inflammatory factor and inducement of hypoxia-inducible factor. |
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