| 吕晓丹,李 瑶,李 航,林森森,袁胜涛.CCL5/CCR5生物学轴在肿瘤中作用的研究进展[J].现代生物医学进展英文版,2017,17(19):3780-3782. |
| CCL5/CCR5生物学轴在肿瘤中作用的研究进展 |
| Progress on CCL5/CCR5 Axis in Cancer |
| Received:December 15, 2016 Revised:January 12, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.19.046 |
| 中文关键词: 趋化因子5 肿瘤 迁移 免疫逃逸 血管生成 |
| 英文关键词: CCL5 Cancer Migration Immune escape Angiogenesis |
| 基金项目:国家自然科学基金项目(81573456，81302794)；江苏省自然科学基金项目（BK20161598）；国家高技术研究发展计划(863计划) （2014AA022208） |
|
| Hits: 370 |
| Download times: 368 |
| 中文摘要: |
| 摘要：肿瘤因其易转移、易复发的特性成为一大难以治愈的疾病，已严重威胁到人类的生命健康。肿瘤微环境在肿瘤的生长、迁移、免疫逃逸、血管生成等过程中具有明显的促进作用。肿瘤微环境中细胞分泌的CCL5发挥的作用已受到越来越多的关注，且许多研究表明抑制CCL5/CCR5生物学轴可抑制肿瘤迁移、血管生成等，预示着这可能成为一个新的肿瘤治疗策略。本文总结了近年来关于CCL5/CCR5生物学轴的研究，包括CCL5/CCR5生物学轴介导的肿瘤生长迁移、血管生成、免疫逃逸等作用，及CCR5抑制剂在肿瘤治疗中的广阔前景。 |
| 英文摘要: |
| ABSTRACT: Tumor is a difficult to cure because of it is easy to transfer and relapse. Tumor microenvironment significantly pro- motes cancer proliferation, metastasis, immune escape and angiogenesis. Chemokine C-C motif ligand 5 (CCL5) produced by cells in the tumor microenvironment act as a key role. Increasing evidences demonstrate attenuation the secretion of CCL5, or inhibition of CCR5, the cognate receptor of CCL5, can inhibit cancer metastasis and angiogenesis. Targeting CCL5-CCR5 axis may be of great significance in the future treatment of cancer. This review summarizes the recent developments of CCL5-CCR5 axis, including various biological func- tions of the axis, such as promotes cancer proliferation, metastasis, immune escape and angiogenesis, and the development of CCR5 in- hibitors as a new anti-cancer treatment. |
|
View Full Text
View/Add Comment Download reader |
| Close |
