| 罗长生,徐 敏,白 冰,刘 全,向小燕.银离子敷料对早期重度烧伤患儿疗效及血清炎性因子水平的影响[J].现代生物医学进展英文版,2017,17(19):3746-3749. |
| 银离子敷料对早期重度烧伤患儿疗效及血清炎性因子水平的影响 |
| Effects of Ag+ Dressings on Clinical Efficacy and Serum Levels of Inflammatory Factors of Children with Early Severe Burns |
| Received:December 22, 2016 Revised:January 19, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.19.037 |
| 中文关键词: 早期重度烧伤 爱康肤银离子敷料 临床疗效 炎性因子 |
| 英文关键词: Early severe burn Ai Kang Fu Ag+ dressings Clinical curative effect Inflammatory cytokines |
| 基金项目:四川省卫生厅科研基金资助项目（100427） |
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| 中文摘要: |
| 摘要 目的：探讨爱康肤银离子敷料在早期重度烧伤患儿中的应用及对炎性因子的影响。方法：98例早期重度烧伤患儿按抽签法分为对照组（n=49）与观察组（n=49），对照组采用磺胺嘧啶银治疗，观察组采用爱康肤银离子敷料治疗。观察并比较两组患者的临床疗效、创面愈合率及感染率，以及治疗前后血清白细胞介素-1（IL-1）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）水平、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、凝血酶原时间（PT）、纤维蛋白原（Fg）及视觉模拟评分（VAS）的变化情况。结果：观察组有效率高于对照组，差异有统计学意义（P<0.05）。观察组创面愈合率高于对照组，创面愈合时间早于对照组，创面感染率低于对照组（P<0.05）。治疗后，观察组IL-1，IL-6，IL-8，TNF-α，APTT，TT及PT均低于对照组，而Fg高于对照组，差异有统计学意义（P<0.05）。结论：爱康肤银离子敷料治疗早期重度烧伤的临床疗效显著，能够降低患儿血清炎性因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To research the effect of Ag+ dressings in treatment of early severe burns and serum levels of inflammatory factors in children. Methods: 98 cases with early severe burns who were treated in our hospital were selected and randomly divided into the control group (n=49) and the observation group (n=49). The patients in the control group were treated with silver sulfadiazine, while the patients in the observation group were treated with Ai Kang Fu Ag+ dressings. Then the clinical curative effect, the rate of cure and in- fection, and the serum levels of interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α), and the activated partial blood coagulation live enzymes time (APTT), thrombin time (TT), prothrombin time (PT), fibrinogen (Fg) and visual analogue scale (VAS) in the two groups were observed and compared before and after the treatment. Results: The effective rate of obser- vation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The wound healing rate of the observation group was better than that of the control group, and the wound infection rate was lower (P<0.05). After treatment, the serum levels of IL-1, IL-6, IL-8 and TNF-α, the APTT, TT and PT of the observation group were lower than those of the control group, while the Fg was higher, and the differences were statistically significant (P<0.05). Conclusion: Ai Kang Fu Ag+ dressings has obvious clinical efficacy on the treatment of early severe burns for children, which can reduce the serum levels of inflammatory factors. |
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