| 阚炳华,蔡 磊,燕归如,申武峰,应可明.腹腔镜与传统开腹手术对胃癌临床疗效、术后并发症及免疫功能的影响比较[J].现代生物医学进展英文版,2017,17(19):3742-3745. |
| 腹腔镜与传统开腹手术对胃癌临床疗效、术后并发症及免疫功能的影响比较 |
| Comparison of the Influence of Laparoscopic and Traditional Open Surgery on the Clinical Effect, Postoperative Complications and Immunologic Functions of Patients with Gastric Cancer |
| Received:October 25, 2016 Revised:November 08, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.19.036 |
| 中文关键词: 腹腔镜手术 胃癌 疗效 并发症 免疫功能 |
| 英文关键词: Laparoscopic surgery Gastric cancer Curative Complications Immunologic functions |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨腹腔镜与传统开腹手术治疗胃癌的临床疗效、安全性及对患者免疫功能的影响。方法：选择2012年3月至2014年3月在我院行胃癌D2根治术的胃癌患者92例并随机分为两组，开腹组(A组)44例接受传统开腹手术，腹腔镜组(B组)48例接受腹腔镜辅助胃癌根治术，观察和比较两组患者的手术情况以及手术前后患者免疫功能的变化，比较两组患者围术期不良反应的发生情况及临床疗效。结果：B组患者术中切口长度、出血量明显优于A组患者(P<0.05)，且B组患者较A组患者术后排气时间以及疼痛缓解情况明显较好(P<0.05)；两组患者接受手术前后，机体的免疫功能有所变化，B组患者术后24 h CD3+、CD4+、CD8+、CD4+/CD8+以及NK细胞相对活性等细胞免疫指标明显高于A组(P<0.05)，体液免疫指标IgM、IgG以及IgA等免疫球蛋白明显高于A组；两组患者术中并发症的发生率差异无统计学意义(P>0.05)，B组患者术后并发症的发生率与A组比较明显降低，且差异具有统计学意义(P<0.05)。结论：腹腔镜辅助胃癌D2根治术对胃癌患者术中临床疗效有显著改善作用，可降低对机体免疫功能的影响并提高治疗的安全性。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the influence of laparoscopic and traditional open surgery on the clinical effect, safety and im- mune function of patients with gastric cancer. Methods: 92 patients of gastric cancer undergoing D2 radical resection were enrolled in our hospital from March 2012 to March 2014, in which patients were randomly divided into two groups: Group A (n=44) accepted traditional open surgery and Group B (n=48) adopted laparoscopic surgery. The clinical of surgery curative and immunologic functions were evalu- ated, and the adverse reactions in perioperative period were recorded and compared. Results: The operative incision lengths and bleeding of Group B were superior to those of Group B (P<0.05), and the postoperative exhaust time of Group B was shorter than that of Group A, the pain relief of Group B was better than that of Group A(P<0.05). The CD3+, CD4+, CD8+, CD4+/CD8+ and NK cell relative activity of cell immunity index was higher in Group B than those of Group A; the fluid immunity index of IgM, IgG and IgA in Group B were higher than those of Group A(P<0.05); no significant difference was observed in the intraoperative complications between two groups (P>0.05), and the incidence of postoperative complications in Group B was lower than that of Group A. Conclusion: Laparoscopic assisted D2 radical gastrectomy significantly improved the clinical curative of gastric cancer, decreased the impact on immune function and enhance the safety. |
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