| 齐晓霞,万晓燕,王 波,牛世勇,高 霞.四君子汤治疗功能性消化不良的临床疗效分析[J].现代生物医学进展英文版,2017,17(19):3734-3737. |
| 四君子汤治疗功能性消化不良的临床疗效分析 |
| Analysis of the Clinical Effect of Si Jun Zi Decoction on the Functional Dyspepsia |
| Received:October 23, 2016 Revised:November 19, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.19.034 |
| 中文关键词: 功能性消化不良 四君子汤 生活质量 血清胃动素(MTL) 胃泌素(GAS) 5-羟色胺(5-HT) 血管活性肠肽(VIP) |
| 英文关键词: Functional dyspepsia Si Jun Zi decoction Living quality Serological marker |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：分析四君子汤治疗功能性消化不良的疗效及对患者生活质量的影响。方法：以2013年1月至2015年12月西安高新医院诊治的132例功能性消化不良患者为研究对象，将其根据就诊顺序分为观察组和对照组，每组66例，对照组给予奥美拉唑肠溶片和多潘立酮片治疗，观察组在对照组的基础之上给予四君子汤加减治疗。比较两组的临床疗效，血清胃动素(MTL)、胃泌素(GAS)、5-羟色胺(5-HT)及血管活性肠肽(VIP)水平以及生活质量评分。结果：治疗后，观察组的总有效率为93.94%，显著高于对照组的78.79%(P<0.05)。治疗后，两组的中医症状积分均较治疗前显著降低(P<0.05)，且观察组显著低于对照组(P<0.05)。观察组治疗后的MTL、GAS水平、生理功能(PF)、社会功能(SP)、生理职能(RP)、情感职能(RE)、躯体疼痛(BP)、活力(VT)、精神健康(MH)和总体健康(GH)评分均较治疗前显著升高(P<0.05)，且明显高于对照组(P<0.05)，5-HT及VIP较治疗前显著降低(P<0.05)，且低于对照组(P<0.05)。结论：四君子汤加减治疗功能性消化不良的临床疗效显著，并可有效提高患者的生活质量，可能与其调节血清MTL、GAS、5-HT、VIP水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the curative effect of Si Jun Zi decoction on patients with functional dyspepsia. Methods: 132 cases of patients with functional dyspepsia in our hospital from January 2013 to December 2015 were divided into the observation group and control group, 66 cases in each group. Patients in the control group were treated with omeprazole enteric-coated capsules and dom- peridone tablets, patients in the observation group were treated with Si Jun Zi Tang on the base of control group therapy. The curative ef- fect, levels of Motilin(MTL), gastrin(GAS), 5-hydroxy-tryptamine(5-HT) and vasoactive intestinal peptide(VIP) and quality of life were compared between two groups. Results: After treatment, the curative effect of observation group(93.94%) was significantly higher than that of the control group(78.79%)(P<0.05). The levels of MTL, GAS and quality of life scores(physiological function (PF), social function (SP), physiological function (RP), functions of emotion (RE), body pain (BP), energy(VT), mental health(MH) and general health(GH)) of observation group were significantly higher than those of the control group(P<0.05), and the levels of 5-HT and VIP of observation group were significantly lower than those of the control group(P<0.05). Conclusion: Si Jun Zi Tang could effectively improve the curative effect, and quality of life of patients with functional dyspepsia, and this might be related to the change of levels of MTL,GAS, 5-HT and VIP. |
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