| 梁鹏飞,李 曦,肖 敏,易显富,郭 辉.脓毒症患者血清炎症因子与SOFA评分的关系研究[J].现代生物医学进展英文版,2017,17(19):3719-3721. |
| 脓毒症患者血清炎症因子与SOFA评分的关系研究 |
| Study on the Relationship Between Serum Inflammatory Factors and SOFA in Patients with Sepsis |
| Received:October 16, 2016 Revised:November 12, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.19.030 |
| 中文关键词: 脓毒症 IL-6 PCT CRP SOFA评分 |
| 英文关键词: Sepsis IL-6 PCT CRP SOFA score |
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| 中文摘要: |
| 摘要 目的：探究脓毒症患者血清炎症因子与序贯器官衰竭评估（SOFA）评分的关系，从而有助于评价患者病情严重程度，科学判断预后效果。方法：选择2014年1月至2015年12月期间在本院内接受治疗的脓毒血症患者142例作为研究对象。入院后24 h内患者进行血清炎症因子IL-6、PCT、CRP水平测定，同时进行SOFA评分。按照患者在入院治疗28天内生存结局状况进行分组，分别为死亡组(87例)和存活组(55例)，另按照患者合并多器官功能障碍综合症(MODS)与否，分为MODS组(76例)和非MODS组(66例)，对比不同组别间IL-6、PCT、CRP及SOFA评分差别；对比不同SOFA评分患者血清IL-6、PCT、CRP水平差异，分析其相关性。结果：IL-6、PCT以及SOFA评分比较，死亡组高于存活组，MODS组高于非MODS组，差异有统计学意义(P<0.05)；SOFA评分越高，血清IL-6、PCT水平越高，差异有统计学意义 (P<0.05)；SOFA评分升高，患者病死率显著增加，SOFA>10分，病死率为78.3%，差异有统计学意义(P<0.05)；Spearman相关分析结果显示，SOFA评分与血清IL-6水平呈显著正相关关系(r=0.261，P=0.012)，与血清PCT水平呈正相关关系(r=0.453，P=0.000)，SOFA与CRP水平无相关性(r=0.112，P=0.323)。结论：血清IL-6、PCT水平与SOFA评分具有相关性，可以在脓毒症患者病情严重程度及预后状况判断中作为生物学指标进行常规监测。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between serum inflammatory factors and sequential organ failure assessment(SOFA) in patients with sepsis, which help to evaluate the severity of the disease, scientific judgment prognosis. Methods: From January 2014 to December 2015,142 cases for treatment of sepsis in our hospital were included as the research objects. Within 24h after admis- sion,patients were detected serum inflammatory factors, such as IL-6, PCT, CRP, so as SOFA. According to the patients in the hospital treatment group survival outcomes in 28 d, respectively, the death group (87 cases) and survival group (55 cases), and according to the patients whether with MODS was divided into MODS group (76 cases) and non MODS group (66 cases). Compare the differences of IL-6, PCT, CRP and SOFA scores between different groups, and compare the serum levels of, PCT and in patients with different SOFA scores, and analyze the correlation. Results: In comparison with IL-6, PCT and SOFA scores, the death group was higher than the survi- val group, the MODS group was higher than the non MODS group, the difference was statistically significant (P<0.05). The higher the SOFA score, serum IL-6, PCT level was higher, the difference was statistically significant (P<0.05); the SOFA score increased, the mor- tality rate was significantly increased, SOFA>10, the fatality rate was 78.3%, the difference was statistically significant (P<0.05); Spear- man correlation analysis showed that SOFA score was positively correlated with serum IL-6 levels (r=0.261, P=0.012), was positively correlated with serum PCT level(r=0.453, P=0.000), there is no correlation between SOFA and CRP levels (r=0.112, P=0.323). Conclusion: Serum IL-6, PCT levels have a correlation with SOFA, and can be used as biological indicators in judging the severity of patients with sepsis and prognosis in routine monitoring. |
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