董建新,韩翠娜,王 艳,江春花,王怡佳.宫颈上皮内瘤变Ⅲ级术后随诊情况及其临床结局分析[J].现代生物医学进展英文版,2017,17(19):3715-3718. |
宫颈上皮内瘤变Ⅲ级术后随诊情况及其临床结局分析 |
Analysis of the Clinical Outcome and Follow-up Results of Patients with Cervical Intraepithelial Neoplasia Grade Ⅲ |
Received:December 06, 2016 Revised:December 30, 2016 |
DOI:10.13241/j.cnki.pmb.2017.19.029 |
中文关键词: 宫颈上皮内瘤变Ⅲ级 术后随诊 HR-HPV 宫颈液基细胞学检查 |
英文关键词: Cervical intraepithelial neoplasia grade Ⅲ Postoperative follow - up HR-HPV TCT |
基金项目:河北省卫生厅医学科学研究重点项目(201607260) |
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中文摘要: |
摘要 目的:探讨宫颈上皮内瘤变Ⅲ级患者宫颈冷刀锥切术后的随访情况,并行TCT及HR-HPV监测对随诊情况进行分析。方法:选择我院2013年6月至2015年6月收治的宫颈冷刀锥切术后诊断为宫颈高级别上皮内瘤变(CINIII,HR-HPV阳性)的患者共计150例,分别于锥切术后3、6、12个月进行HR-HPV检测、宫颈液基细胞学(TCT)检查,并分析其随访情况。结果:不同年龄段患者正规随访比例分别为73.91%、78.05%、68.09%、75%,差异无统计学意义(P>0.05)。正规随访患者术后3、6、12个月,HR-HPV的转阴率分别为57.27%、77.27%、89.09%,不同年龄段HR-HPV的转阴率分别为94.12%、93.75%、87.5%、66.67%,随着年龄的增长HR-HPV转阴率逐渐下降,而大于56岁的患者HR-HPV转阴率最低,与其他各年龄段比较,差异具有统计学意义(P<0.05),各组正规随访患者TCT检查在随访期间均为阴性。结论:宫颈锥切术能够切除宫颈病变组织,但不能完全清除HR-HPV病毒,术后对各年龄段人群均需严密随诊。 |
英文摘要: |
ABSTRACT Objective: To explore the clinical outcome and follow-up results of patients with cervical intraepithelial neoplasia grade Ⅲ. Methods: 150 patients with cervical intraepithelial neoplasia grade III who were admitted for the first time in our hospital from June 2013 to June 2015 were followed up. Results: The rates of regular follow-up were 73.91%, 78.05%, 68.09%, 75% in different age groups. There was no statistical difference between different age groups(P>0.05). The negative rate was 57.27% after three months, 77.27% after six months, 89.09% after twelve months in regular follow up patients. The negative rates of HR-HPV were 94.12%, 93.75%, 87.5%, 66.67% in different age groups. And the HR-HPV negative rate of more than 56-year-old patients was the lowest, com- pared with other age groups(P<0.05). TCT was negative in different age groups. Conclusion: Cervical conization could remove diseased tissues, but couldn't clear the HPV virus. We should pay attention to follow the patients. |
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