| 李向红,薛 翔,哈灵侠,刘春莲,陈 庆,卢小宁.百令胶囊对多囊卵巢综合征患者卵泡液骨形态蛋白、生长分化因子-9及胰岛素样生长因子的影响[J].现代生物医学进展英文版,2017,17(19):3668-3671. |
| 百令胶囊对多囊卵巢综合征患者卵泡液骨形态蛋白、生长分化因子-9及胰岛素样生长因子的影响 |
| Effects of Bailing Capsule on the Follicular Fluid Bone Morphogenetic Protein, Growth Differentiation Factor -9 and Insulin Like Growth Factor of Patients with Polycystic Ovary Syndrome |
| Received:December 26, 2016 Revised:January 21, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.19.016 |
| 中文关键词: 多囊卵巢综合征 百令胶囊 骨形态蛋白 生长分化因子 胰岛素样生长因子 |
| 英文关键词: Polycystic ovary syndrome Bailing capsules Bone morphogenetic protein Growth differentiation factor Insulin like growth factor |
| 基金项目:陕西省自然科学基础研究计划项目（2016JM8067） |
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| 中文摘要: |
| 摘要 目的：探讨百令胶囊对多囊卵巢综合征患者卵泡液骨形态蛋白(BMP)、生长分化因子(GDF)-9及胰岛素样生长因子(IGF)的影响。方法：选择2013年7月至2016年7月我院接诊的90例多囊卵巢综合征患者，通过随机数表法分为观察组(n=45)和对照组(n=45)，对照组使用达英-35治疗，观察组在此基础上使用百令胶囊。比较两组糖代谢指标、内分泌指标、卵泡液BMP-15、GDF-9、IGF-1水平的变化以及临床疗效。结果：治疗后，观察组空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗(HOMA-IR)、血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)水平水平均显著低于对照组(P＜0.05)，卵泡液BMP-15、GDF-9水平显著高于对照组，IGF-1水平明显低于对照组(P＜0.05)，总有效率显著高于对照组(P＜0.05)。结论：百令胶囊质量多囊卵巢综合征效果显著，可有效调节内分泌，并改善卵泡液BMP-15、GDF-9、IGF-1的水平。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effects of bailing capsules on levels of follicular fluid bone morphogenetic protein (BMP), growth differentiation factor -9(GDF) and insulin like growth factor (IGF) of patients with polycystic ovary syndrome. Methods: 90 pa- tients with polycystic ovary syndrome who had received therapy from July 2013 to July 2016 in our hospital were selected and randomly divided into the observation group (n=45) and the control group (n=45). The patients in the control group were treated with Diane -35, while the patients in the observation group were treated with bailing capsules on the basis of the control group. Then the levels of glucose metabolism index, endocrine index, BMP-15, GDF-9 and IGF-1 and clinical curative effect between the two groups were observed and compared before and after the treatment. Results: After treatment, the levels of fasting blood glucose (FBG), fasting insulin (FINS) and insulin resistance (HOMA-IR) in the observation group were lower than those of the control group (P＜0.05); the levels of follicle stimu- lating hormone (FSH), luteinizing hormone (LH), testosterone (T) in the observation group were lower than those of the control group (P＜0.05); the levels of BMP-15 and GDF-9 in the observation group were higher than those of the control group, and the levels of IGF-1 was lower than that of the control group (P＜0.05); the total effective rate of the observation group was higher than that of the control group (P＜0.05). Conclusion: Bailing capsules was effective for polycystic ovary syndrome, which could effectively regulate the en- docrine and improve the expression of BMP-15, GDF-9 and IGF-1 in the follicular fluid. |
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