| 潘丰慧,杨海燕,王 惠,李 曼,胡 云.女性年龄相关的性激素水平与骨代谢指标的关系[J].现代生物医学进展英文版,2017,17(18):3579-3582. |
| 女性年龄相关的性激素水平与骨代谢指标的关系 |
| Relationship of Age-related Levels of Serum Sex Hormones with Bone Metabolism Markers in Women |
| Received:January 05, 2017 Revised:January 24, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.18.042 |
| 中文关键词: 性激素 骨代谢指标 女性 |
| 英文关键词: Sex hormones Bone metabolism markers Female |
| 基金项目:江苏省卫计委科研基金项目（BJ15005） |
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| 中文摘要: |
| 摘要 目的：探讨女性性激素水平与骨代谢指标的关系。方法：202例女性按年龄分为<40、40~49、50~59、60~69、≥70岁组，用化学发光法测定血清卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、睾酮（TES）和骨钙素（OC）、I型胶原羟基端肽β特殊序列（β-CTX）、I型前胶原氨基端前肽（PINP）。比较各组间性激素水平与骨代谢指标的差异，并进一步分析其相关性。结果：血清FSH和LH随年龄增长而升高，50岁以后达高峰；E2随年龄增长而降低，50岁以后各年龄组显著低于49岁以下年龄组（P<0.05）；血清OC、β-CTX、PINP随年龄增长而升高，50岁以后各年龄组显著高于49岁以下年龄组（P<0.05）。校正年龄后，血清FSH、LH与OC、β-CTX呈显著正相关，E2与β-CTX呈显著负相关（均P<0.01）。将FSH、LH、E2水平由低到高分成四等分组，随着FSH、LH的递增，OC、β-CTX逐渐递增；随着E2水平的递增，β-CTX逐渐递减（趋势P均<0.05）。多元线性回归分析显示，FSH与β-CTX独立正相关（β=0.218, P=0.033），LH与OC独立正相关（β=0.322, P=0.004），而E2与OC、β-CTX、PINP均未见独立相关性。结论：女性骨代谢与循环中性激素水平变化有关，其主要影响因素可能是FSH、LH水平的增加，雌激素水平的下降可能起次要作用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between serum sex hormones and bone metabolism markers. Methods: Total of 202 women were divided into <40, 40~49, 50~59, 60~69, and ≥ 70 years groups. The serum concentrations of FSH, LH, E2, TES and OC, PINP, β-CTX were measured by chemiluminescence. The differences of serum sex hormones and bone metabolism markers were compared among the groups, as well as the correlation between them were analysed. Results: The levels of serum FSH and LH were in- creased with age, and reached the peak after 50 years old. The level of serum E2 was decreased with age, after 50 years groups were sig- nificantly lower than before 49 years groups (P<0.05). The levels of serum OC, β-CTX, PINP were increased with age, after 50 years groups were significantly higher than before 49 years groups (P<0.05). After adjusting age, serum FSH and LH had markedly positive correlation with OC and β-CTX, and serum E2 had markedly negative correlation with β-CTX (all P<0.01). FSH, LH and E2 were di- vided into quartiles. With the increased quartiles of serum FSH and LH, OC and β-CTX were increased, while β-CTX was decreased with the increased quartiles of serum E2(all P for trend < 0.05). Multiple linear regression analysis revealed that serum FSH was indepen- dently positive associated with β-CTX(β= 0.218, P=0.033), and LH was independently positive associated with OC(β= 0.322, P=0.004). While, there was no independent correlation between E2 and OC, β-CTX, PINP. Conclusion: Bone metabolism is correlated with serum sex hormones in women. The most critical factor for bone metabolism is FSH and LH, while a decreased level of estrogen may be sec- ondary. |
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