| 徐兰英,杨国春,王艳丽,黄 茜,刘胜玉.脾多肽注射液对原发性肝癌患者超声学改变及AFP水平的影响[J].现代生物医学进展英文版,2017,17(18):3574-3578. |
| 脾多肽注射液对原发性肝癌患者超声学改变及AFP水平的影响 |
| Effects of Lienal Polypeptide Injection on Ultrasound Changes and Serum Levels of AFP in Patients with Primary Liver Cancer |
| Received:January 08, 2017 Revised:January 26, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.18.041 |
| 中文关键词: 原发性肝癌 脾多肽注射液 彩超 AFP 疗效 |
| 英文关键词: Primary liver cancer Lienal polypeptide injection Color doppler AFP Clinical effect |
| 基金项目:辽宁省科技厅计划项目(2013226012) |
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| 中文摘要: |
| 摘要 目的：探讨脾多肽注射液对原发性肝癌患者超声学改变及AFP水平的影响。方法：选取我院肿瘤科收治的原发性肝癌患者168例，随机分为对照组和研究组，每组84例。对照组患者予以经导管动脉化疗栓塞术（TACE）治疗，研究组在对照组基础上予以脾多肽注射液治疗。观察并比较两组患者治疗前后肿瘤血供情况、血清肿瘤标志物水平、外周血免疫细胞水平、临床疗效及不良反应发生率。结果：研究组治疗有效率高于对照组，差异具有统计学意义（P＜0.05）；与对照组比较，研究组治疗后肿瘤内动脉、肿瘤周边动脉血流分级水平较低，肿瘤周边门脉血流分级水平较高，治疗后血清AFP、CA19-9、GGT、AFU水平较低，治疗后外周血NK细胞、CD4+、CD4+/CD8+比值水平较高，CD8+T淋巴细胞水平较低（P＜0.05）；研究组恶心呕吐、食欲不振、白细胞减少、发热、乏力疲劳等不良反应的发生率低于对照组（P＜0.05）。结论：脾多肽注射液能够有效减少原发性肝癌患者肿瘤组织的血供，降低AFP、CA19-9、GGT、AFU水平，减轻免疫抑制，提高临床疗效，降低不良反应的发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the influence of lienal polypeptide injection on ultrasound and serum levels of AFP in patients with primary liver cancer. Methods: 168 patients with primary liver cancer who were treated in our hospital were selected and divided into the control group and the experiment group, with 84 cases in each group. The patients in the control group were treated with transcatheter arterial chemoembolization (TACE), while the patients in the experiment group were treated with lienal polypeptide injection on the basis of the control group. Then the tumor blood supply, serum tumor marker levels, peripheral blood immune cell levels, the clinical effect and the incidence of adverse reactions in the two groups were observed and compared before and after the treatment. Results: The effective rate in the experiment group was higher than that of the control group, and the difference was statistically significant (P<0.05); Compared with the control group, the blood flow classification levels of intra tumor artery and peripheral tumor artery were lower, blood flow classification level of tumor peripheral portal vein was higher, serum levels of AFP, CA19-9, GGT and AFU were lower, peripheral blood NK cell, CD4+T lymphocyte and CD4+/CD8+ ratio levels were higher, and CD8+T lymphocyte level was lower in the experiment group after treatment (P<0.05); The incidence of adverse reactions including the nausea and vomiting, loss of appetite, leukopenia, fever and fatigue in the experiment group was lower than that of the control group (P<0.05). Conclusion: Lienal polypeptide injection can significantly reduce the blood supply of tumor tissue in patients with primary liver cancer, reduce the levels of AFP, CA19-9, GGT, AFU, reduce the inhibitory on immune functions, improve the clinical effect, and reduce the incidence of adverse reactions. |
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