| 何仲春,肖慧宇,石顺华,马丽霞,冯 荣.血栓通联合低分子肝素治疗对急性冠脉综合征患者PCI术后炎症因子及内皮功能的影响[J].现代生物医学进展英文版,2017,17(18):3540-3543. |
| 血栓通联合低分子肝素治疗对急性冠脉综合征患者PCI术后炎症因子及内皮功能的影响 |
| Effect of Xueshuantong Combined with Low Molecular Heparin on Inflammatory Factors and Endothelial Function in Patients with Acute Coronary Syndrome after PCI |
| Received:February 15, 2017 Revised:March 10, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.18.033 |
| 中文关键词: 血栓通 低分子肝素 急性冠脉综合征 经皮冠脉动脉介入治疗 内皮功能 炎症因子 |
| 英文关键词: Xueshuantong Low molecular Heparin Acute coronary syndrome Percutaneous coronary intervention Endothelial function Inflammatory factor |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨血栓通联合低分子肝素治疗对急性冠脉综合征（ACS）患者经皮冠脉动脉介入治疗（PCI）术后炎症因子及内皮功能的影响。方法：选择我院于2015年10月~2016年10月间收治的ACS患者共92例，经随机数字表法分为观察组及对照组各46例，PCI术后给予对照组患者常规治疗，观察组在对照组的基础上加用血栓通注射液联合低分子肝素治疗，两组患者均连续治疗2周。检测两组患者高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、总胆固醇（TC）、甘油三酯（TG）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、血浆内皮素-1（ET-1）、不对称二甲基精氨酸（ADMA）、超敏C-反应蛋白（hs-CRP）水平，统计两组患者心绞痛、心肌梗死发生情况。结果：治疗后观察组HDL水平高于对照组，LDL、TC、TG水平低于对照组（P＜0.05）；治疗后观察组TNF-α、IL-6、ET-1、ADMA、hs-CRP水平低于对照组（P＜0.05）。两组心脏事件发生率差异无统计学意义（P>0.05）。结论：血栓通联合低分子肝素治疗行PCI术的ACS患者，可显著改善患者血脂水平，减轻炎症反应，改善血管内皮功能，值得临床推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Xueshuantong combined with low molecular heparin on inflammatory factors and endothelial function in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods:Selected 92 patients with ACS in our hospital from October 2015 to October 2016. The patients were randomly divided into observation group and control group, with 46 cases in each group. After PCI, the control group was given conventional treatment, while the observation group was treated with Xueshuantong injection combined with low molecular heparin on the basis of the control group. Two groups of patients were treated for 2 weeks. Detected the levels of high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA), high sensitive C-reactive protein (hs-CRP), and statisted the incidence of angina pectoris and myocardial infarction in two groups. Results: After treatment, the level of HDL in observation group was higher than the control group, the levels of LDL, TC, TG were lower than the control group(P<0.05); the levels of TNF-α, IL-6, ET-1, ADMA, hs-CRP in observation group after treatment were lower than the control group(P<0.05). The incidence of cardiac events between the two groups was no significant difference(P>0.05). Conclusion: Xueshuantong combined with low molecular heparin can significantly improve the level of blood lipids,reduce inflammation and improve endothelial function, in patients with ACS after PCI, it is worth promoting. |
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