| 熊慧丽,赵晓宏,周庆元,柳 杨,王佳丹.依替膦酸二钠对老年性骨质疏松症的疗效及安全性分析[J].现代生物医学进展英文版,2017,17(18):3532-3535. |
| 依替膦酸二钠对老年性骨质疏松症的疗效及安全性分析 |
| Effects and Safety of Etidronate in Senile Osteoporosis |
| Received:September 29, 2016 Revised:October 25, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.18.031 |
| 中文关键词: 骨质疏松症 依替膦酸二钠 骨密度 Trap-5b Balp |
| 英文关键词: Osteoporosis Etidronate Bone mineral density Trap-5b Balp |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：分析依替膦酸二钠对老年性骨质疏松症的疗效及安全性。方法：以2013年1月至2016年6月在西安交通大学附属三二0一医院门诊及住院部接受治疗的老年骨质疏松症患者60例为研究对象，将60例患者按照接受治疗时间顺序分为观察组和对照组，每组30例。对照组给予钙尔奇D片治疗，观察组在对照组的基础之上加用依替膦酸二钠，两组治疗时间12个月。比较两组的疗效及安全性。结果：治疗后，观察组的股骨颈骨密度和腰椎骨密度均治疗前升高（P<0.05），对照组治疗前与治疗后比较，差异无统计学意义（P 0.05）；观察组治疗后的股骨颈和腰椎骨密度均高于对照组（P<0.05）。治疗后，观察组的骨密度治疗显效率和总有效率均高于对照组（P<0.05）。治疗后，观察组和对照组的视觉模拟评分法（VAS）评分均较治疗前降低（P<0.05），观察组的VAS评分低于对照组，观察组的腰背疼痛治疗显效率及总有效率均高于对照组，差异有统计学意义（P<0.05）。治疗后，观察组Trap-5b水平较治疗前下降（P<0.05），观察组的Balp和对照组的Trap-5b和Balp水平较治疗前有下降趋势，但无差异无统计学意义（P 0.05）；观察组治疗后的Trap-5b水平均低于对照组（P<0.05）。两组的不良反应发生率比较，观察组高于对照组（P<0.05）。结论：依替膦酸二钠可有效改善老年性骨质疏松症患者的骨密度及骨疼痛，有效降低Trap-5b和Balp水平，抑制破骨过程，但不良反应发生率较高，临床需综合评估患者情况合理选择用药。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effects and safety of etidronate in senile osteoporosis. Methods: 60 cases of senile osteoporosis in our hospital from January 2013 to June 2016 were divided into observation group(n=30) and control group(n=30).The patients in the observation group were treated with etidronate and caltratewith vitamin D tablets, and the patients in the control group were treated with caltrate with vitamin D tablets. The effects and safety were compared between two groups after treatment for 12 weeks. Results: After treatment, the femur neck and lumber bone mineral density (BMD) of the observation group was significantly higher than before treatment and that of the control group（P<0.05）, but there was no difference in the control group before and after treatment（P 0.05）. The total effective rate of BMD of the observation group after treatment were significantly higher than that of the control group（P<0.05）. After treatment, the visual Analogue Scale/Score(VAS) scores of the observation group and control group were significantly lower than before treatment（P<0.05）, and the VAS scores of the observation group was significantly lower than that of the control group（P<0.05）, and the total effective rate of lumbodorsal of the observation group was significantly higher than that of the control group（P<0.05）.The level of Trap-5b of the observation group after treatment was significantly lower than before treatment and the control group（P<0.05）, and the level of Balp of the observation group and the levels of Trap-5b and Balp of the control group were reduced, but there was no significant difference（P<0.05）. The adverse reaction rate of the observation group was significantly higher than that of the control group（P<0.05）. Conclusion: The etidronatecan effectively improve BMD and lumbodorsal, reduce Trap - 5 b and Balp levels, inhibit the osteoclasts process in treatment of senile osteoporosis, but the rate of adverse reactions is a bit high, so it is necessary to choose rational treatment project according to thesituation of patients. |
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