| 李海峰,蒋秋英,卢丽先,李 蕾,陆 慧.涎腺腺样囊性癌组织中COX-2, Survivin及livin的表达及临床意义[J].现代生物医学进展英文版,2017,17(18):3509-3512. |
| 涎腺腺样囊性癌组织中COX-2, Survivin及livin的表达及临床意义 |
| Expression and Clinical Significance of COX-2, Survivin and Livin in Salivary Adenoid Cystic Carcinoma |
| Received:March 02, 2017 Revised:March 31, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.18.025 |
| 中文关键词: 涎腺腺样囊性癌 COX-2 Survivin livin 相关性 |
| 英文关键词: Salivary adenoid cystic carcinoma COX-2 Survivin Livin Correlation |
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| 中文摘要: |
| 摘要 目的：探究涎腺腺样囊性癌（SACC）组织中COX-2、Survivin及livin的表达及临床意义。方法：收集2013年1月~2016年11月我院肿瘤外科收治的63例SACC患者癌变病理组织标本与30例SACC患者癌旁正常组织标本为研究对象；应用免疫组化法（SP法）检测COX-2、Survivin及livin蛋白在SACC组织和正常组织中的表达情况，分析SACC组织COX-2、Survivin及livin的表达与临床病理特征的关系，采用Spearman秩相关分析COX-2、Survivin及livin之间的关系。结果：Survivin、livin及COX-2在SACC组织中的阳性率依次为66.67%（42/63）、57.14%（36/63）及73.02%（46/63），其阳性主要表达于肿瘤细胞胞浆或胞膜上，而正常组织细胞中未发现阳性表达；Survivin、livin及COX-2在不同性别、年龄、肿瘤部位的阳性率无统计学差异（P>0.05）；实体型、淋巴转移、中低分化及III+IV期患者Survivin、livin及COX-2的阳性率高于筛孔型+管状型、淋巴未转移、高分化、I+II期患者，差异均有统计学意义（P<0.05）；Spearman秩相关显示，Survivin与COX-2呈正相关（r=0.632，P<0.05）；livin与COX-2呈正相关（r=0.453，P<0.05）；Survivin与livin无相关（r=0.143，P>0.05）。结论：Survivin、livin及COX-2在SACC患者中呈高表达，可能对SACC的发生、发展具有促进作用；Survivin、livin及COX-2可作为临床早期筛查SACC并预测疾病转归的指标。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression and clinical significance of COX-2, Survivin and livin in salivary adenoid cystic carcinoma(SACC) tissues. Methods: The cancerous pathological specimens of 63 patients with SACC in our hospital and 30 cases of adjacent normal tissues specimens patients with SACC, who were admitted to Handan Central Hospital of Hebei Province from January 2013 to November 2016, were selected as research subjects.Immunohistochemical method (S-P method) was used to study the expression of COX-2, Survivin and livin protein in pathological tissues and normal tissues of SACC. The relationship between the expression of COX-2, Survivin and livin in the tissues of SACC and clinical pathological features was analyzed, and Spearman rank correlation analysis was used to analyze the relationship between COX-2, Survivin and livin. Results: There was no relationship between survovin and livin.（r=0.143, P>0.05）. The positive expression rates of Survivin, livin and COX-2 in SACC pathological tissues were 66.67%(42/63), 57.14%(36/63) and 73.02%(46/63) respectively, and the positive expression was mainly expressed in the cytoplasm or membrane of tumor cells, while no positive expression was found in normal cells. There was no significant difference in the positive rates of Survivin, livin and COX-2 in different gender, age and tumor location(P>0.05). The positive rates of Survivin, livin and COX-2 in patients with entity type, lymph node metastasis, low differentiation and III+IV stage were higher than those of patients with sieve + tubular type, lymph metastasis, high differentiation and I+II stage, the difference was statistically significant (P<0.05). Spearman rank correlation showed that Survivin was positively correlated with COX-2 (r=0.632, P<0.05), livin was positively correlated with COX-2 (r=0.453, P<0.05), Survivin and livin had no correlation (r=0.143, P>0.05). Conclusion: Survivin, livin and COX-2 were highly expressed in SACC patients, which may promote the occurrence and development of SACC. Survivin,livin and COX-2 can be used as an early screening for SACC and as predicting the outcome of the disease. |
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