| 张成锋,习耀峰,陈 荣,贾 伟,刘 强.微型游离腓动脉穿支皮瓣修复术治疗手部小创面感染的效果及对血清炎性因子的影响[J].现代生物医学进展英文版,2017,17(17):3355-3358. |
| 微型游离腓动脉穿支皮瓣修复术治疗手部小创面感染的效果及对血清炎性因子的影响 |
| Clinical Effect of Free Peroneal Artery Perforator Flap on the Small Wound of Hand Infection and Its Effects on the Serum Inflammatory Factors |
| Received:December 12, 2016 Revised:December 27, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.17.039 |
| 中文关键词: 手部小创面 微型游离腓动脉穿支皮瓣修复 感染 炎性因子 |
| 英文关键词: Small wound of hand Free peroneal artery perforator flap Infection Inflammatory factor |
| 基金项目:陕西省自然科学基金项目(1208M5326) |
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| 中文摘要: |
| 摘要 目的：探讨微型游离腓动脉穿支皮瓣修复在手部小创面感染中的应用效果及对血清炎性因子的影响。方法：选择2014年10月至2016年10月我院接诊的90例手部小创面患者，通过随机数表法分为观察组(n=45)和对照组(n=45)，对照组行游离腹壁下动脉穿支皮瓣修复，观察组行微型游离腓动脉穿支皮瓣修复。比较两组患者手术效果、血清白介素(IL)-6、IL-8、干扰素(INF)-γ、肿瘤坏死因子(TNF)-α、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平的变化及感染发生率。结果：与手术前比较，两组患者手术后白介素(IL)-6、IL-8、干扰素(INF)-γ、肿瘤坏死因子(TNF)-α、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、红细胞沉积率(ESR)水平均显著升高(P＜0.05)，且观察组以上指标均显著低于对照组(P＜0.05)。观察组术后优良率明显高于对照组[86.67%(39/45)vs64.44%%(29/45)](P＜0.05)，术后感染率显著低于对照组[2.22%(1/45)vs17.78%(8/45)](P＜0.05)。结论：微型游离腓动脉穿支皮瓣修复治疗手部小创面的临床效果显著，术后炎症反应轻，感染发生率低。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of free peroneal artery perforator flap on the small wound of hand infection and its effects on the serum inflammatory factors. Methods: 90 patients with small wound of hand who were treated in our hospital from Oc- tober 2014 to October 2016 were selected and divided into the observation group (n=45) and the control group (n=45). according to the random number table. The control group was treated with inferior epigastric artery perforator flap repair, while the observation group was treated with free peroneal artery perforator flap. Then the operative effect and serum interleukin (IL)-6, IL-8, interferon(INF)-γ, tumor necrosis factor (TNF)-α, procalcitonin(PCR), high sensitive C reactive protein(hs-CRP) levels before and after treatment as well as the in- cidence of infection were compared between two groups. Results: Compared with those before operation, the levels of serum IL-6, IL-8, INF-γ, TNF-α, procalcitonin(PCR), high sensitive C reactive protein(hs-CRP), erythrocyte sedimentation rate (ESR) of both groups were significantly decreased, which were obviously lower in the observation group than those of the control group(P＜0.05); the excellent and good rate after operation in the observation group was higher than that of the control group (P＜0.05); the infection rate of the observa- tion group was lower than that of the control group(P＜0.05). Conclusion: Free peroneal artery perforator flap was effective and safe for small wound of hand, which could significantly inhibit the inflammatory response and desease the postoperative infection. |
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