| 杜晓琴,兰云竹,郑茜文,潘长青,齐成秋.多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症患者血清IL-17，TNF-α，TGF-β水平的影响[J].现代生物医学进展英文版,2017,17(17):3339-3342. |
| 多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症患者血清IL-17，TNF-α，TGF-β水平的影响 |
| Effects of Polyene Phosphatidyl Choline on the Serum Levels of IL-17, TNF-α and TGF-β of Patients with Intrahepatic Cholestasis During Pregnancy |
| Received:December 06, 2016 Revised:December 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.17.035 |
| 中文关键词: 妊娠期肝内胆汁淤积症 多烯磷脂酰胆碱 白细胞介素-17 肿瘤坏死因子-α 转化生长因子-β 临床疗效 |
| 英文关键词: Intrahepatic cholestasis disease during pregnancy Polyene phosphatidyl choline Interleukin-17 Tumor necrosis fac- tor-α Transforming growth factor-β Curative effect |
| 基金项目:四川省卫生厅科研基金项目(130212) |
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| 中文摘要: |
| 摘要 目的：分析多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症患者血清白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)水平的影响及临床疗效。方法：选择我院2014年6月~2016年6月收治的102例妊娠期肝内胆汁淤积症患者，按抽签法分为对照组与观察组，各51例。对照组行常规治疗，观察组在对照组治疗基本上加以多烯磷脂酰胆碱治疗，比较两组治疗前后IL-17、TNF-α、TGF-β、血管内皮生长因子(VEGF)、总胆汁酸(TBA)，直接胆红素(DBiL)、总胆红素(TBiL)、谷草转移氨酶(AST)、谷丙转氨酶(ALT)、瘙痒评分的变化、有效率及妊娠结局。结果：治疗后，观察组血清IL-17、TNF-α、TGF-β、VEGF、TBA、DBiL、TBiL、AST、ALT水平及瘙痒评分均显著低于对照组，有效率明显高于对照组，不良妊娠结局率显著低于对照组，差异均有统计学意义(P<0.05)。结论：多烯磷脂酰胆碱可有效提高妊娠期肝内胆汁淤积症的临床疗效，降低血清IL-17、TNF-α、TGF-β水平，改善妊娠结局。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the effect of polyene phosphatidyl choline on the serum nterleukin-17 (IL-17), tumor necrosis factor-α(TNF-α), transforming growth factor beta-β(TGF-β) of patients with intrahepatic cholestasis during pregnancy. Methods: 102 cases of patients with intrahepatic cholestasis during pregnancy from June 2014 to June 2016 were selected and divided into control group and observation group according to the draw method with 51 cases in each group. The control group was treated by routine treat- ment, while the observation group was treated by polyene phosphatidyl choline based on the control group. The serum IL-17, TNF-α, TGF-β, vascular endothelial growth factor (VEGF) and total bile acid (associates), direct bilirubin (DBiL), total bilirubin (TBiL), straw transfer ammonia enzyme (AST), alanine aminotransferase (ALT) levels, pruritus score, efficient and pregnancy outcome were compared between two groups. Results: The serum IL-17, TNF-α, TGF-β, VEGF, TBA, DBiL, TBiL, AST, ALT levels and pruritus score of obser- vation group were significantly lower than those the control group, the effective rate was higher than that of the control group, the adverse pregnancy outcome rate was lower than that of the control group(P<0.05). Conclusion: Polyene phosphatidyl choline could effectively en- hance the efficacy of intrahepatic cholestasis during pregnancy, decrease the serum IL-17, TNF-α, TGF-β levels and improve the preg- nancy outcome. |
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