| 周 慧,刘 振,李长贵,赵金娇,崔凌凌,路 杰.痛风与单纯性高尿酸血症人群高脂血症的对比分析[J].现代生物医学进展英文版,2017,17(17):3278-3281. |
| 痛风与单纯性高尿酸血症人群高脂血症的对比分析 |
| Comparative Analysis of the Hyperlipidemia between Gout and Simple Hyperuricemia Patients |
| Received:December 05, 2016 Revised:December 27, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.17.019 |
| 中文关键词: 痛风 单纯性高尿酸血症 脂代谢 |
| 英文关键词: Gout Simple hyperuricemia Lipid metabolism |
| 基金项目:国家自然科学基金项目(81500346，31471195)；青岛市应用基础研究计划项目(青年专项)(14-2-4-73-jch、15-9-1-98-jch)；青岛博士后项目（2015149） |
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| 中文摘要: |
| 摘要 目的：对比分析痛风与单纯高尿酸血症合并高脂血症的情况。方法：收集青岛大学附属医院痛风专病门诊2009年5月至2016年1月收治的痛风患者7207例(男性6759例，女性448例)，单纯高尿酸血症患者2095例(男性1852例，女性243例)。测量受试者身高、体重、腰围、臀围、血压、空腹血糖(FPG)、血甘油三酯(TG)、血胆固醇(TC)及血尿酸(UA)，计算并比较两组高甘油三脂血症、高胆固醇血症的患病率，并分析其在痛风发生中的独立作用。结果：痛风组高甘油三酯血症和高胆固醇血症的患病率分别为57.8 %、47.5 %；单纯高尿酸血症组为51.8 %、52.9 %；两组率相比的比值比，高甘油三脂血症1.274[95 %CI(1.155, 1.404)]，胆固醇血症0.805[95 %CI (0.730, 0.887)]。按性别分层分析，男性痛风组高甘油三脂血症、高胆固醇血症患病率分别为56.2 %，46.8 %；单纯高尿酸血症组分别为52.3 %，52.6 %。两组率相比的比值比，高甘油三脂血症1.25[95CI %(1.13, 1.39)]，高胆固醇血症0.80[95CI %(0.72, 0.89)]。女性中痛风组高甘油三脂血症、高胆固醇血症患病率分别为52.2 %，58.90 %；单纯高尿酸血症组分别为46.6 %，58.0 %；两组差异无统计学意义。高甘油三脂血症与痛风的发生正相关OR=1.29, 95 %CI(1.12, 1.48)，高胆固醇血症与痛风的发生负相关OR=0.80, 95 %CI(0.73, 0.89)。结论：痛风与单纯高尿酸血症患者存在不同的脂代谢状态，高甘油三酯血症可能是单纯高尿酸血症发展为痛风的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To compare and analyze the lipid metabolism between gout and simple hyperuricemia(HUA) patients. Methods: A Total of 7207 patients (6759 males and 448 females) with gout and 2095 patients (1852 males and 243 females) with simple HUA from the gout clinic of Affiliated Hospital of Qingdao University between May 2009 and January 2016 were enrolled in this study. The height, weight, waistline, hipline, blood pressure, fasting plasma glucose (FPG), triglyceride (TG), cholesterol (TC) and uric acid (UA) of both groups were monitored. Compute and compare the incidence of hypertriglyceridemia, and hypercholesteremia. And analyze the independent effect of them in the simple HUA developing gout. Results: the incidence of hypertriglyceridemia, and hyperc- holesteremiain gout is 57.8 %, 47.5 %, in simple HUA is 51.8 %, 52.9 %. Compare the incidence rates between two groups by odds ra- tios, hypertriglyceridemia is 1.274[95 %CI(1.155, 1.404)]; hypercholesteremia is 0.805[95 %CI (0.730, 0.887)]. Stratification analysis by gender, we find that the difference of lipid metabolism mainly occourred in male. Hypertriglyceridemia had positive association with gout OR=1.29, 95 %CI(1.12, 1.48), while hypercholesteremia had negative association with gout OR=0.80, 95 %CI(0.73, 0.89). Conclusion: Gout and simple HUA had different lipid metabolism; hypertriglyceridemia may be an independent risk factor for simple HUA develop- ing gout. |
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