| 杨立安,张震波,冯 伟,杨福泉,胡 帅.普罗卡因联合头孢曲松治疗急性胰腺炎的临床疗效研究[J].现代生物医学进展英文版,2017,17(16):3140-3143. |
| 普罗卡因联合头孢曲松治疗急性胰腺炎的临床疗效研究 |
| Curative Efficacy of Procaine Combined with Cefatriaxone in Treatment of Acute Pancreatitis |
| Received:November 03, 2016 Revised:November 16, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.16.036 |
| 中文关键词: 急性胰腺炎 头孢曲松 普罗卡因 降钙素原 D-乳酸 |
| 英文关键词: Acute pancreatitis Cefatriaxone Procaine Procalcitonin D-Lactate |
| 基金项目:陕西省自然科学基金项目(2009FJ6053） |
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| 中文摘要: |
| 摘要 目的：探讨普罗卡因联合头孢曲松对急性胰腺炎患者临床疗效及肠粘膜屏障功能的影响。方法：选择2013年8月至2016年8月我院接诊的92例急性胰腺炎患者，通过随机数表法分为观察组（n=46）和对照组（n=46）。对照组使用头孢曲松钠治疗，观察组在对照组基础上联用普罗卡因。比较两组临床症状缓解时间、治疗前后血清肿瘤坏死因子（TNF-α）、白介素（IL）-6、超敏C反应蛋白（hs-CRP）、降钙素原和D-乳酸水平及临床疗效。结果：观察组腹痛缓解时间、腹胀缓解时间、禁食时间、血清淀粉酶恢复正常时间均比对照组短（P＜0.05）；治疗后，观察组血清TNF-α、IL-6、hs-CRP、降钙素原、D-乳酸水平均显著低于对照组（P＜0.05），总有效率明显高于对照组（P＜0.05）。结论：普罗卡因联合头孢曲松可有效缓解急性胰腺炎患者的临床症状，降低机体炎性反应，促进肠粘膜屏障功能的恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative efficacy of procaine combined with cefatriaxone in treatment of acute pancreatitis and its effects on serum levels of procalcitonin and D-Lactate. Methods: 92 patients with acute pancreatitis who were treated in our hospital from August 2013 to August 2016 were selected and randomly divided into the control group (n=46) and the observation group (n=46). The patients in the control group were treated with cefatriaxone, while the patients in the observation group were treated with the procaine on the basis of the control group. Then the remission time of clinical symptoms, and the serum levels of the tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), high sensitive C reactive protein (hs-CRP), procalcitonin and D-Lactate, and the clinical efficacy of the two groups were observed and compared before and after the treatment. Results: The relief time of abdominal pain and distension, the fasting time, and the recovery of serum amylase in the observation group were shorter than those of the control group (P<0.05); The serum levels of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), high sensitive C reactive protein (hs-CRP) and D-Lactate of the observation group were lower than those of the control group (P<0.05); The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). Conclusion: Procaine combined with cefatriaxon has better clinical effect on the treatment of acute pancreatitis, which can effectively alleviate the clinical symptoms, reduce the serum levels of inflammatory response, and promote the recovery of intestinal mucosal barrier functions, and it's worthy of clinical application. |
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