| 潘险峰,李 瑛,袁仲飞,黄国威,唐 妮,陈 刚.丹参酮ⅡA注射液联合前列地尔治疗糖尿病肾病的疗效观察[J].现代生物医学进展英文版,2017,17(16):3118-3121. |
| 丹参酮ⅡA注射液联合前列地尔治疗糖尿病肾病的疗效观察 |
| Clinical Effect of Alprostadil Jointed with Tanshinone ⅡA Injection on Patient with Diabetic Nephropathy |
| Received:December 03, 2016 Revised:December 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.16.030 |
| 中文关键词: 糖尿病肾病 丹参酮ⅡA 前列地尔 疗效 |
| 英文关键词: Diabetic nephropathy Tanshinone ⅡA Alprostadil Effect |
| 基金项目:重庆市教委科学技术研究项目（KJ1400233） |
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| 中文摘要: |
| 摘要 目的：探究丹参酮ⅡA注射液联合前列地尔治疗糖尿病肾病的临床疗效。方法：选取我院于2014年10月至2015年10月期间收治的糖尿病肾病患者100例为研究对象， 按照随机数字表法分为研究组和对照组各50例；对照组给予前列地尔，研究组给予前列地尔与丹参酮ⅡA注射液，比较两组患者总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇(LDL-C)以及血尿素氮（BUN）, 24 h尿蛋白定量及肌酐（Cre）的水平。结果：治疗前两组患者间各项指标均无显著性差异（P>0.05）；治疗后两组患者TC、TG、LDL-C、Cre、BUN、24 h尿蛋白定量较治疗前均出现明显降低，HDL-C较治疗前明显升高（P<0.05）；研究组患者TC、TG、LDL-C、Cre、BUN、24 h尿蛋白定量均低于对照组，HDL-C高于对照组（P<0.05）；两组患者均未出现严重不良反应。结论：丹参酮ⅡA注射液联合前列地尔治疗糖尿病肾病可以改善患者的血脂水平，降低肌酐，尿蛋白，缓解肾脏损伤，具有明显的临床疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of alprostadil jointed with tanshinone ⅡA injection on patient with diabetic nephropathy. Methods: 100 cases of patients with diabetic nephropathy treated in our hospital from October 2014 to October 2015 were selected as research object, which were divided into research group and control group according to the random number table method, 50 cases in each group. The control group was given alprostadil, while the research group received alprostadil and Tanshinone ⅡA injection. Compared the level of total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), serum creatinine(Cre), blood urea nitrogen(BUN), 24 h urinary albumin between the two groups. Results: There was no significant difference on each index between the two groups before treatment(P>0.05), and the levels of TC, TG, LDL-C, Cre, BUN, 24 h urinary albumin were significantly declined and the level of HDL-C was significantly increased after treatment in each group(P<0.05). Levels of TC, TG, LDL-C, Cre, BUN, 24 h urinary albumin in research group were significant lower than control groups after treatment(P<0.05), while the level of HDL-C was higher(P<0.05). There were no serious adverse reaction occurred in the two groups. Conclusion: Alprostadil jointed with tanshinoneⅡA injection in the treatment of the patients with diabetic nephropathy can improve the blood lipid levels, reduce Cre and 24h urinary albumin, and alleviate renal injury, which has obvious clinical efficacy. |
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