| 曹 焱,潘慧丽,郑光浩,张 超,胡 东.三维适形放疗联合替吉奥胶囊口服化疗治疗局部晚期胃癌疗效观察[J].现代生物医学进展英文版,2017,17(16):3107-3110. |
| 三维适形放疗联合替吉奥胶囊口服化疗治疗局部晚期胃癌疗效观察 |
| Clinical Effect of 3D-CRT Combined with Tegafur Gimeracil Oteracil Capsule in Treatment of Locally Advanced Gastric Cancer |
| Received:July 27, 2016 Revised:August 24, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.16.027 |
| 中文关键词: 局部晚期胃癌 三维适形放疗 替吉奥 疗效 |
| 英文关键词: Locally advanced gastric cancer 3D-CRT Tegafur gimeracil oteracil capsule Effect |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨三维适形放疗联合替吉奥胶囊口服化疗治疗局部晚期胃癌的疗效及安全性。方法：收取2010年1月至2015年1月于我院治疗的局部晚期胃癌患者126例作为研究对象进行回顾性分析，根据治疗方法的不同将其分为观察组65例及对照组61例。对照组患者仅进行三维适形放疗，观察组在此基础上加用替吉奥胶囊口服。对两组患者近期疗效、不良反应发生情况、生活质量以及远期疗效进行观察与比较。结果：观察组患者RR及DCR分别为67.69 %及87.69 %，对照组RR及DCR分别为34.43 %及67.21 %，观察组近期疗效明显优于对照组（P<0.05）。观察组患者各系统不良反应发生率高于对照组，但差异不显著（P>0.05）。观察组患者生活质量改善总有效率为86.15 %，明显高于对照组70.49 %。观察组患者1年生存率明显高于对照组（P<0.05），但3年生存率及5年生存率两组相差不显著（P>0.05）。结论：三维适形放疗联合替吉奥胶囊口服具有良好的临床疗效，有助于提高患者生存率及生存质量，但可能会提高不良反应发生风险，需根据患者具体情况设计治疗方案。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect and safety of 3-dimensional conformal radiation therapy (3D-CRT) combined with tegafur gimeracil oteracil capsule (S-1) in treatment of locally advanced gastric cancer. Methods: 126 patients accepted in our hospital from January 2010 to January 2015 were retrospectively analyzed and divided into observation group with 65 cases and control group with 61 cases according to different treatment methods. The patients in control group were given 3D-CRT only, but the patients in observation group were given S-1 additionally. Then the short-term effect, adverse reactions, life quality and long-term effect of two groups were observed and compared. Results: The RR and DCR of observation group was 67.69 % and 87.69 % respectively, and the RR and DCR of control group was 34.43 % and 67.21 % respectively. The short-term effect of observation group was obviously better than that of control group with statistically significance (P<0.05). The adverse reactions of each systems of observation group were higher than those of control group but without statistically difference (P>0.05). The improvement rate of life quality in observation group was 86.15 %, which was obviously higher than 70.49 % of control group with statistically significance (P<0.05). 1-year survival rate of observation group was remarkably higher than that of control group but there was no statistically difference in 3-year and 5-year survival rate between two groups (P>0.05). Conclusion: Using 3D-CRT combined with S-1 has good effect and is helpful improving survival rate and life quality, but it will also improve the risk of adverse reactions. The treatment methods must be designed according to patients' specific conditions. |
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