| 龚 阳,李 锐,罗国刚,郭媛媛,管昭锐,刘学东.糖皮质激素联合免疫球蛋白治疗机械通气的吉兰巴雷综合征的临床疗效分析[J].现代生物医学进展英文版,2017,17(16):3086-3090. |
| 糖皮质激素联合免疫球蛋白治疗机械通气的吉兰巴雷综合征的临床疗效分析 |
| Clinical Efficacy of Corticosteroids combination IVIG on Patients of Guillain-Barré Syndrome with Mechanically Ventilated |
| Received:November 22, 2016 Revised:December 16, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.16.022 |
| 中文关键词: 吉兰-巴雷综合征 机械通气 糖皮质激素 免疫球蛋白 疗效分析 |
| 英文关键词: Guillain-Barré syndrome Mechanical ventilation Corticosteroids Intravenous immunoglobulin Efficacy |
| 基金项目:陕西省科技攻关基金项目(2011k14-07-02) |
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| 中文摘要: |
| 摘要 目的：分析糖皮质激素联合免疫球蛋白治疗需要机械通气的吉兰巴雷综合征的临床疗效。方法：回顾性分析2008年1月至2016年7月西安市六家医院收治的采用机械通气的吉兰巴雷综合征患者的临床资料，并对其进行随访，比较单用免疫球蛋白与糖皮质激素联合免疫球蛋白的疗效差异。结果：两组在出院时及出院后6个月的总有效率(MRC及HFGS的改善率)、死亡率、机械通气时间、住院时间、在ICU住院时间、出院时及出院后6个月的MRC总得分和HFGS得分以及并发症发生率比较差异均无统计学意义(P>0.05)。结论：对于机械通气的吉兰巴雷综合征患者，在使用免疫球蛋白的基础上增加糖皮质激素的使用，对其短期(出院时)及较长期(出院后6个月)的临床疗效和安全性均无显著影响。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical efficacy of corticosteroids combined with IVIG for Guillain-Barré Syndrome treated by mechanical ventilation. Methods: The clinical data of patients with Guillain-Barré Syndrome treated by mechanical ventilation from six hospitals in xi'an from January 2008 to July 2016 were retrospectively analyzed and followed up, the efficacy which was compared between IVIG and corticosteroids combined with IVIG treatment. Results: The efficacy between IVIG treatment group and corticosteroids combination IVIG treatment group showed no significant difference in the improvement rate of MRC sum-score and HFGS score, mortality, mechanical ventilation time, hospital time, time in ICU, the MRC sum-score and HFGS score at discharge and at 6 months and incidence of complications. Conclusion: For patients with Guillain-Barré Syndrome treated by mechanical ventilation, the short-time (discharge) and longer-time (6 months after discharge) clinical efficacy and security of corticosteroids combined with IVIG treatment was equal to corticosteroids alone. |
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