| 魏庆宇,朱晓明,李全生,江盛学,李欣泽.胎盘多肽注射液对慢性湿疹患者血清TNF-2α, INF-γ和ECP水平的影响[J].现代生物医学进展英文版,2017,17(16):3057-3059. |
| 胎盘多肽注射液对慢性湿疹患者血清TNF-2α, INF-γ和ECP水平的影响 |
| Effect of Placenta Polypeptide on Serum Levels of TNF-2α, INF-γ and ECP in Patients with Chronic Eczema |
| Received:December 14, 2016 Revised:December 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.16.014 |
| 中文关键词: 慢性湿疹 胎盘多肽 肿瘤坏死因子-2α 干扰素-γ 嗜酸细胞阳离子蛋白 |
| 英文关键词: Chronic eczema Placenta polypeptide injection Tumor necrosis factor2α Interferon-γ Eosinophilic cationic protein |
| 基金项目:辽宁省科学事业公益研究基金项目（2012001010） |
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| 中文摘要: |
| 摘要 目的：探讨胎盘多肽注射液治疗慢性湿疹的疗效观察及对血清肿瘤坏死因子（TNF）-2α、干扰素（INF）-γ、嗜酸细胞阳离子蛋白（ECP）水平的影响。方法：选择2014年5月至2016年5月我院接诊的86例慢性湿疹患者，通过随机数表法分为观察组（n=43）和对照组（n=43）。对照组给予常规治疗，观察组在对照组基础上加用胎盘多肽注射液。观察并比较两组患者治疗前后血清TNF-2α，INF-γ及ECP水平、临床疗效及复发率。结果：治疗后，观察组TNF-2α、INF-γ、ECP水平均比对照组低（P＜0.05）；观察组红斑、丘疹、表皮脱落、苔藓化症状得分均优于对照组（P＜0.05）；观察组总有效率比对照组高（P＜0.05）；在随访的3个月中，观察组复发率比对照组低（P＜0.05）。结论：在慢性湿疹患者中应用胎盘多肽注射液效果显著，可有效缓解临床症状，增加机体免疫力，提高预后，值得应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of placenta polypeptide injection on serum levels of tumor necrosis factor (TNF)-2α, interferon(INF)-γ and eosinophilic cationic protein(ECP) in patients with chronic eczema. Methods: 86 patients of chronic eczema who received therapy from May 2014 to May 2016 in our hospital were selected and randomly divided into the observation group (n=43) and the control group (n=43). The patients in the control group were treated with conventional method, while the patients in the observation group were treated with placenta polypeptide injection. Then the serum levels of ECP, INF-γ and TNF-2α, clinical efficacy and recurrence rate between the two groups were observed and compared. Results: After treatment, the serum levels of ECP, INF-γ and TNF-2α in the observation group were lower than those of the control group (P<0.05); The erythema, population, excoriation and lichenification in the observation group were better than those of the control group (P<0.05); The total effective rate in the observation group was higher than that of the control group (P<0.05); The recurrence rate of the observation group was lower than that of the control group (P<0.05). Conclusion: Placenta polypeptide injection is well for chronic eczema, which can effectively alleviate clinical symptoms,increase the body immunity, improve the prognosis, it' s worthy of application and promotion. |
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