| 刘成勇,夏云玲,彭 琼,李 娟,张 雯.MIF mRNA在胃窦胃癌组织中的表达及其与幽门螺杆菌感染的关系[J].现代生物医学进展英文版,2017,17(15):2965-2968. |
| MIF mRNA在胃窦胃癌组织中的表达及其与幽门螺杆菌感染的关系 |
| Expressions of MIF mRNA in Gastric Antrum Cancer and Its Relationship with Helicobacter Pylori Infections |
| Received:January 22, 2017 Revised:February 17, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.15.043 |
| 中文关键词: 巨噬细胞移动抑制因子 幽门螺杆菌 胃窦胃癌 胃窦胃炎 |
| 英文关键词: Macrophage migration inhibitory factor Helicobacter pylori Gastric antrum cancer Gastric antrum gastritis |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨胃窦胃癌组织中人巨噬细胞移动抑制因子MIF mRNA的表达，并分析其与幽门螺杆菌感染的关系，分析二者在胃窦胃癌发生中的相关性。方法：选取2013年1月至2014年12月于我院收治的胃窦胃癌患者30例作为观察组，另随机选择10例胃窦胃炎患者作为对照组，采用14C-尿素呼气试验（UBT）检测各组患者有无幽门螺杆菌感染，定量逆转录PCR检测观察组患者及对照组患者组织中MIF mRNA表达。统计分析不同组织中MIF mRNA表达与幽门螺杆菌感染之间的关系。结果：观察组组织中MIF mRNA的表达为（1.09±0.11），高于对照组组织的（0.21±0.08），差异具有统计学意义（P<0.05）。进一步亚组分析，观察组合并幽门螺杆菌感染组织中MIF mRNA的表达为(1.24±0.14），高于非幽门螺杆菌感染者的（1.09±0.11），差异具有统计学意义（P <0.05）。结论：MIF mRNA在胃窦胃癌组织中高表达，幽门螺杆菌感染促进了MIF mRNA的表达，共同促进了胃窦胃癌的发生发展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the human MIF mRNA expression in tissues from patients with gastric antrum cancers and to analyze its relationship with Helicobacter pylori infections in the development of gastric antrum cancer. Methods: 30 patients with gastric antrum cancer in our hospital from January 2013 to December 2014 were selected as observation group, and 10 patients with gastric antral gastritis were randomly selected as control group. 14C-urea breath test(UBT) was used to detect Helicobacter pylori infections or not in each group, and quantitative reverse transcription PCR was used to detect the levels of MIF mRNA expression in the tissues from the patients of the observation group and the control group. Statistically analysised the relationship between the expression of MIF mRNA in different tissues and Helicobacter pylori infection. Results: The level of MIF mRNA expression in tissues from observation group was (1.09±0.11), which was significantly higher in tissues from control group (0.207±0.08), the difference was statistically significant (P<0.05). Trough further subgroup analysis,the levels of MIF mRNA expression in Hp infection patients with gastric antrum cancer were (1.24±0.14), which were significantly higher those in non-Hp infection patients (1.09±0.11), the difference was statistically significant (P<0.05). Conclusion: MIF mRNA is highly expressed in gastric antrum carcinoma, and Helicobacter pylori infection promotes the expression of MIF mRNA, and they promote together the development of gastric antrum cancer. |
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