| 鲁 慧,王彬成,崔宁宁,邵汝升,张艳春.缺血预适应预防和治疗老年脑梗塞的疗效观察[J].现代生物医学进展英文版,2017,17(15):2941-2943. |
| 缺血预适应预防和治疗老年脑梗塞的疗效观察 |
| Efficacy of Ischemic Preconditioning in the Prevention and Treatment of Elderly Patients with Cerebral Infarction |
| Received:October 15, 2016 Revised:October 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.15.037 |
| 中文关键词: 缺血预适应 老年脑梗塞 预防 治疗 |
| 英文关键词: Ischemic preconditioning Elderly patients with cerebral infarction Prevention Treatment |
| 基金项目:河北省自然科学基金项目(2000J050)；河北省沧州市科技支撑计划项目（131302161） |
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| 中文摘要: |
| 摘要 目的：探讨缺血预适应在老年脑梗塞患者预防和治疗中的临床疗效。方法：选取我院治疗的老年脑梗塞患者64例，按随机数字表法分组，对照组32例患者予以临床常规治疗，研究组32患者在对照组的基础上予以缺血预适应治疗，治疗6个月，测定并记录两组间美国国立卫生院神经功能缺损评分(NIHSS)、Barthel指数(BI)及生活质量，同时对比患者临床疗效、疾病复发率、死亡率及不良反应的发生情况。结果：对照组治疗有效率为显著低于研究组，差异具有统计学意义(P＜0.05)。与对照组比较，研究组治疗后NIHSS积分较低，BI评分较高，差异具有统计学意义(P＜0.05)；研究组复发率及死亡率均明显低于对照组，差异具有统计学意义(P＜0.05)。结论：缺血预适应对老年脑梗塞患者的预防效果显著，可有效提高患者的生活质量，降低死亡率和复发率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of ischemic preconditioning in the prevention and treatment of elderly patients with cerebral infarction. Methods: 64 elderly patients with cerebral infarction who were treated in our hospital were selected and randomly divided into two groups, 32 cases in the control group were treated by clinical routine treatment, 32 cases in the experimental group was treated on the base of control group with ischemic preconditioning treatment, the treatment lasted for 6 months, then the US national in- stitutes of health neural function defect score (NIHSS), Barthel index (BI) and quality of life were measured and compared between the two groups. The clinical efficacy, disease recurrence rate, mortality and incidence of adverse reactions were compared. Results: The ef- fective rate of control group was 71.88 %, which was significantly lower than that of the experimental group(93.75 %, P<0.05). Com- pared with the control group, the NIHSS score of the experiment group was lower after treatment, BI score was higher, the quality of life improved more outstanding (P<0.05); the recurrence rate and mortality of experimental group were significantly lower than those of the control group (P<0.05). Conclusion: Ischemic preconditioning was effective to prevent and treat elderly patients with cerebral infarction, which could effectively improve the quality of life, reduce the mortality and recurrence. |
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