| 王少丽,韩 蓁,董 晋,张 明,谭秋花.氟康唑胶囊联合知柏地黄丸治疗滴虫性阴道炎的疗效及对患者血清IL-10和TNF-?琢水平的影响[J].现代生物医学进展英文版,2017,17(15):2917-2919. |
| 氟康唑胶囊联合知柏地黄丸治疗滴虫性阴道炎的疗效及对患者血清IL-10和TNF-?琢水平的影响 |
| Effect of Fluconazole Capsules Combined with Zhibaidihuangwan on the Serum Levels of IL-10 and TNF-?琢 and Clinical Effect of Patients with Trichomonas Vaginitis |
| Received:October 28, 2016 Revised:November 21, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.15.030 |
| 中文关键词: 氟康唑胶囊 知柏地黄丸 滴虫性阴道炎 白细胞介素-10 肿瘤坏死因子-α |
| 英文关键词: Fluconazole Capsules Zhibaidihuang pill Trichomonas vaginitis IL-10 TNF-α |
| 基金项目:陕西省自然科学基金项目(2010H091) |
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| 中文摘要: |
| 摘要 目的：探讨氟康唑胶囊联合知柏地黄丸对滴虫性阴道炎患者血清白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)的影响及临床疗效。方法：收集我院就诊的78例滴虫性阴道炎患者，随机分为实验组和对照组，各39例。对照组患者给予氟康唑胶囊治疗，实验组在对照组基础上给予知柏地黄丸治疗。观察并比较两组患者治疗前后IL-10、TNF-α、阴道健康评分及临床疗效。结果：与治疗前相比，两组患者治疗后血清IL-10、TNF-α水平均显著下降，阴道健康评分均明显升高，差异具均有统计学意义(P<0.05)；与对照组相比，实验组患者治疗后血清IL-10、TNF-α水平较低，阴道健康评分和临床治疗总有效率均较高，差异均具有统计学意义(P<0.05)。结论：氟康唑胶囊联合知柏地黄丸能够有效提高滴虫性阴道炎患者的临床疗效，可能与其显著降低血清IL-10、TNF-α水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of fluconazole capsule combined with Zhibaidihuangwan on the serum IL-10, TNF-α levels and clinical effect of patients with trichomonas vaginitis. Methods: 78 cases of trichomonas vaginitis patients were collected in our hospital and randomly divided into the experimental group and control group, with 39 cases in each group. Patients in the control group were treated with fluconazole, and patients in the experimental group were treated with fluconazole AND Zhibaidihuangwan. Then the changes of serum levels of interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α) and the vaginal health score as well as the clinical efficacy were observed and compared before and after treatment. Results: Compared with before treatment, the serum TNF-α, IL-10 levels in both groups of patients after treatment were decreased, the vagina health score were significantly increased(P<0.05); com- pared with the control group, the serum IL-10, TNF-α levels were obviously lower of patients in the experimental group, the vagina health score and total efficiency were significantly higher of patients in the experimental group(P<0.05). Conclusion: Fluconazole capsule combined with Zhibaidihuangwan could effectively enhance the clinical curative effect of trichomonad vaginitis patients, which might be related to the reduction of serum IL-10 and TNF-α levels. |
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