| 张 鹏,蒋兰兰,罗 勇,许向红,袁 璐,马建华.2型糖尿病患者血清LDL，CysC与动脉粥样硬化的相关性研究[J].现代生物医学进展英文版,2017,17(15):2862-2864. |
| 2型糖尿病患者血清LDL，CysC与动脉粥样硬化的相关性研究 |
| The Relationship between Levels of LDL, CysC and Atherosclerosis in Patients with Type 2 Diabetes Mellitus |
| Received:November 30, 2016 Revised:December 25, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.15.015 |
| 中文关键词: 2型糖尿病 动脉粥样硬化 低密度脂蛋白 胱抑素C 颈动脉内-中膜厚度 |
| 英文关键词: Type 2 diabetes mellitus Atherosclerosis Low density lipoprotein Cystatin C Intima-media thickness |
| 基金项目:江苏省自然科学计划项目（20140152） |
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| 中文摘要: |
| 摘要 目的：分析2型糖尿病（T2DM）患者血清低密度脂蛋白（LDL）、胱抑素C（CysC）与动脉粥样硬化（AS）的相关性。方法：选取2型糖尿病患者300名，根据颈动脉内膜中膜厚度分为非动脉粥样硬化斑块组（n=109）和动脉粥样硬化斑块组（n=191），并对动脉粥样硬化斑块的相关危险因素进行多因素Logistic回归分析。结果：（1）Pearson相关分析显示，LDL、CysC水平与IMT值呈正相关（P<0.05）。（2）单因素分析示，非AS组和AS组两组间LDL（t=8.876，P<0.05）、CysC（t=7.985，P<0.05）、HbA1c（t=9.912，P<0.05）、Hs-CRP（t=12.461，P<0.05）、年龄（t=7.114，P<0.05）、UA（(t=8.618，P<0.05）间差异有统计学意义；（3）多因素Logistic回归分析示，LDL、CysC、HbA1c、年龄是T2DM并AS的独立危险因素（P<0.05）；结论：LDL与CysC水平是T2DM并AS的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the relationship between levels of low density lipoprotein(LDL), Cystatin C (CysC) and Atherosclerosis (AS) in patients with Type 2 diabetes mellitus(T2DM). Methods: 300 cases with T2DM were selected. According to the carotid intima-media thickness (IMT), patients were divided into two groups: AS group (n=191) and non-AS group (n=109). A multi-fac- tor Logistic regression was performed to analyze the risk factors associated with the incidence of T2DM complicated with AS. Results: (1) Pearson correlation analysis indicated that CysC and LDL levels were positively correlated with IMT (P<0.05); (2) Univariate analysis showed that the incidence of AS was associated with HbA1c (t=9.912, P<0.05), CysC (t=7.985, P<0.05), LDL (t=7.592, P<0.05), age (t=7.114, P<0.05), UA (t=8.618, P<0.05), Hs-CRP (t=12.461, P<0.05). (3) Multi-factor Logistic regression indicated that LDL, CysC, HbA1c and age were the independent risk factors for the onset of AS (P<0.05). Conclusion: It is proved that LDL and CysC were the in- dependent risk factors for the onset of AS with T2DM. |
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