| 徐金平,莫丽娟,文 萍,陈 刚,王大平.替加环素对多重耐药鲍曼不动杆菌引起重症肺炎患者的临床疗效[J].现代生物医学进展英文版,2017,17(14):2743-2746. |
| 替加环素对多重耐药鲍曼不动杆菌引起重症肺炎患者的临床疗效 |
| Clinical Effect of Tigecycline in Treatment of Severe Pneumonia Infected by Multiple Drug Resistant of Acinetobacter Bauman |
| Received:November 06, 2016 Revised:November 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.14.036 |
| 中文关键词: 替加环素 多重耐药鲍曼不动杆菌 重症肺炎 |
| 英文关键词: Tigecycline Multiple drug resistant Acinetobacter Bauman Severe pneumonia |
| 基金项目:海南省自然科学基金项目(L12H10569) |
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| 中文摘要: |
| 摘要 目的：探讨替加环素治疗多重耐药鲍曼不动杆菌引起的重症肺炎的临床疗效。方法：回顾性研究我院多重耐药鲍曼不动杆菌引起的重症肺炎60例，随机分为对照组和实验组，每组30例。对照组患者给予头孢哌酮舒巴坦治疗，实验组患者应用替加环素治疗。观察并比较两组患者治疗前后血清降钙素原（PCT）、C反应蛋白（CRP）及白细胞计数（WBC）的变化情况、不良反应情况、细菌清除情况及临床疗效。结果：与治疗前相比，两组患者血清PCT、CRP及WBC水平均降低（P＜0.05）；与对照组相比，实验组患者血清PCT、CRP及WBC水平较低（P＜0.05）；实验组不良反应发生率及再感染率低于对照组（P＜0.05）；实验组细菌清除率及临床总有效率高于对照组（P＜0.05）。结论：对于由多重耐药鲍曼不动杆菌引起的重症肺炎，替加环素具有很好的临床疗效，值得在临床上推广使用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical curative effect of tigecycline in the treatment of severe pneumonia infected bu the multiple drug resistant of acinetobacter bauman. Methods: 60 patients with severe pneumonia infected by the multiple drug resistant of acinetobacter bauman who were treated in our hospital were selected and randomly divided into the control group and the experiment group. The patients in the control group were treated with cefoperazone and sulbactam, while the patients in the experiment group were treated with tigecycline. Then the serum levels of procalcitonin (PCT) and C reactive protein (CRP), the white blood cell count (WBC), the adverse reactions, the bacterial clearance and clinical effect in the two groups were observed and compared before and after the treatment. Results: Compared with before treatment, the serum levels of PCT, CRP and WBC were lower in the two groups (P<0.05). Compared with the control group, the serum levels of PCT, CRP and WBC were lower in the experiment group after the treatment (P<0.05); Compared with the control group, the incidence of adverse reactions and the re-infection rate were lower in the experiment group, while the bacterial clearance rate and the clinical total effective rate were higher (P<0.05). Conclusion: Tigecycline has better clinical effect on the treatment of the severe pneumonia infected by the multi drug resistant of acinetobacter bauman, and it is worthy of clinical application. |
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