| 黄 勇,张晓青,金忠芹,唐伟国,武庆斌.慢性胃炎组织病理特征和Hp感染与炎症程度的关系研究[J].现代生物医学进展英文版,2017,17(14):2707-2710. |
| 慢性胃炎组织病理特征和Hp感染与炎症程度的关系研究 |
| The Relationship between Characteristic of Pathohistology with Hp Infection and Degree of Inflammation in Chronic Gastritis |
| Received:August 31, 2016 Revised:September 25, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.14.026 |
| 中文关键词: HP感染 炎症程度 肠化分级 慢性胃炎 |
| 英文关键词: HP infection Degree of inflammation Grading of intestinal metaplasia Chronic gastritis |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨慢性胃炎组织病理特征和Hp感染与慢性炎症程度的关系。方法：抽选我院2010年1月至2016年2月行胃镜检查诊断为慢性胃炎的467例患儿，作胃窦黏膜病理组织学检查，并检测有无HP感染，分析HP感染与慢性胃炎病理特征、慢性炎症程度之间的关系。结果：在病理检查中，轻度、中度、重度炎症反应患儿HP感染率（7.7%、41.2%、51.1%）依次升高，且差异具有统计学意义（P<0.05），有炎症活动度患儿的HP阳性率76.3%明显高于无炎症活动度患儿23.7%（P<0.05）。随着肠化分级加重、淋巴滤泡形成、萎缩程度分级升高等病理变化，Hp阳性率明显升高（P<0.05）。轻度、中度、重度炎症三组淋巴滤泡形成、肠化生和胃萎缩发生率明显呈递增趋势，Hp阳性率明显呈递增趋势，比较差异显著（P<0.05）。结论：Hp是慢性胃炎发病的重要影响因素，与患儿胃窦黏膜炎症程度、活动性、淋巴滤泡形成、肠化分级以及黏膜萎缩萎等病理变化密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between Characteristic of Pathohistology, Helicobater Pylori and Degree of inflammation in Chronic Gastritis. Methods: 467 cases of chronic gastritis children in our hospital from January 2010 to February 2016 for gastroscopy diagnosis were selected. The histological features of gastric antrum mucosa were examined, and the positive rate of HP was detected, and the relationship between HP infection and pathological features of chronic gastritis and the degree of chronic inflammation was analyzed. Results: In the pathological examination, the HP infection rate in children with mild, moderate and severe inflammatory reaction (7.7%, 41.2%,51.1%) was increased, and the difference was statistically significant (P<0.05). The positive rate of HP in children with inflammatory activity of 76.3% was significantly higher than that in children with no inflammatory activity for 23.7% (P<0.05). The positive rate of Hp was significantly increased with the increase of the grade of intestinal metaplasia, the formation of lymphoid follicles and the degree of atrophy. The incidence of lymph follicle formation, intestinal metaplasia and gastric atrophy in three groups of mild, moderate and severe inflammation was significantly increased, Hp positive rate was significantly increased,and the difference was significant (P<0.05). Conclusion: HP infection is important factor in the pathogenesis of chronic gastritis,is closely related with gastric mucosal inflammation, activity, lymph follicle formation, intestinal mucosal atrophy atrophy grading and other pathological changes. |
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