| 任美田,苏占海,张耀刚,唐智伟,沈国双.FGFR4 mRNA及蛋白在乳腺癌组织中的表达及临床意义[J].现代生物医学进展英文版,2017,17(14):2646-2649. |
| FGFR4 mRNA及蛋白在乳腺癌组织中的表达及临床意义 |
| Expression and Clinical Significance of FGFR4 mRNA and Protein in the Breast Cancer |
| Received:December 19, 2016 Revised:January 12, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.14.010 |
| 中文关键词: 乳腺癌 FGFR4 淋巴结转移 临床病理特征 |
| 英文关键词: Breast cancer FGFR4 Clinical and pathological characteristics Lymph node metastasis |
| 基金项目:青海省科技厅应用基础研究项目(2016-ZJ-762) |
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| 中文摘要: |
| 摘要 目的：研究乳腺癌组织与乳腺癌癌旁组织中FGFR4 mRNA及蛋白的表达及其临床意义。方法：分别以实时荧光定量RT-PCR、Western blot的方法检测52 例乳腺癌组织和52 例癌旁正常组织中FGFR4 mRNA和蛋白的表达，分析FGFR4 mRNA和蛋白的表达与临床病理特征的相关性。结果：在乳腺癌组织中，FGFR4 mRNA及蛋白的表达均高于在乳腺癌癌旁正常组织(P<0.05)，并且FGFR4的表达与患者淋巴结转移和Her-2相关，而与患者年龄、肿瘤大小、分化程度、ER和PR无明显相关性(P>0.05)。结论：FGFR4 mRNA及蛋白在乳腺癌组织中表达升高，与淋巴结转移和Her-2有关，有望成为预测乳腺癌的转移和预后的参考指标之一。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expression and clinical significance of FGFR4 mRNA and protein in the breast cancer tissues and adjacent tissues. Methods: Real-time fluorescence quantitative RT-PCR and Western blot methods were used respectively to detect the expression of FGFR4 mRNA and protein in 52 cases of breast cancer tissues and adjacent tissues. Results: The expressions of FGFR4 mRNA and protein in the breast cancer tissues were higher than those of the adjacent tissues(p<0.05), and they were associated with the lymph node metastasis and Her-2 expression(p<0.05), but had no correlation with the age, tumor size, degree of differentiation, ER and PR of breast cancer(P>0.05). Conclusion: FGFR4 mRNA and protein expressions in the breast cancer tissue were relate to the lymph node metastasis and Her-2 expression. FGFR4 mRNA and protein were expected to be the indicatiors of breast cancer metastasis and prognosis. |
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