叶雪瑞,尹 力,崔金金,吕 勃,于 波.SIRT3与细胞凋亡的研究进展[J].现代生物医学进展英文版,2017,17(13):2586-2589. |
SIRT3与细胞凋亡的研究进展 |
Progress of Correlation between SIRT3 and Cells Apoptosis |
Received:April 25, 2016 Revised:May 20, 2016 |
DOI:10.13241/j.cnki.pmb.2017.13.048 |
中文关键词: SIRT3 凋亡 线粒体通透性转换孔 氧自由基 |
英文关键词: SIRT3 Apoptosis Mitochondrial permeability transition pore Reactive oxygen species |
基金项目:国家自然科学基金重点项目(81330033) |
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中文摘要: |
摘要:SIRT3是哺乳动物体内"sirtuin家族"7成员之一,是一种NAD依赖的组蛋白去乙酰化酶,主要存在于线粒体内。SIRT3存在两种形式:44 kDa的长链和28 kDa的短链,其在细胞内主要通过短链SIRT3发挥作用。SIRT3通过其酶催化活性,除了可调节机体能量代谢、细胞衰老以及肿瘤形成等生命过程外,SIRT3对于细胞凋亡也起到举足轻重的调节作用。目前的研究表明,在细胞凋亡中,SIRT3可能存在双向调节作用,即通过不同的信号通路的作用,SIRT3可促进/抑制细胞凋亡而发挥一系列的生物学效应,而有关于SIRT3调节细胞凋亡更详尽的分子机制还有待深入研究。 |
英文摘要: |
ABSTRACT: SIRT3 is one of the seven members of "Sirtuin family" inside the mammals. It is a kind of histone deacetylase mainly existed in the mitochondria as the dependence of NAD. SIRT3 has two kinds of forms: a long chain length of 44 kDa and a short chain length of 28 kDa, SIRT3 plays a role in the intracellular mainly through the short chain. In addition to regulates the body's energy metabolism, cell senescence and tumorigenesis of life process, SIRT3 also plays a regulatory role for apoptosis through its catalytic activ- ity of enzyme. Current research suggests that SIRT3 probably has the function of bidirectional regulation in apoptosis, it means through different signal pathway, SIRT3 can promote/inhibit apoptosis so that induces a series of biological effects, but the molecular mechanism of regulation of apoptosis is more detailed and need further research. |
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