| 倪莎莎,陈蓓蕾,马依晨,李 艳,柳文婧,李鸿馨,张进军.儿科住院患儿下呼吸道感染的病原菌分布及耐药性分析[J].现代生物医学进展英文版,2017,17(13):2546-2549. |
| 儿科住院患儿下呼吸道感染的病原菌分布及耐药性分析 |
| Study on the Distribution and Drug Resistance Status of the Pathogen of Lower Respiratory Infections in Hospitalized Children |
| Received:December 08, 2016 Revised:December 29, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.13.038 |
| 中文关键词: 儿科住院患儿 呼吸道感染 病原菌分布 耐药性 |
| 英文关键词: Hospitalized children in pediatrics Respiratory tract infection Pathogen distribution Drug resistance |
| 基金项目:陕西省宝鸡市卫生局科研立项（2012-16号） |
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| 中文摘要: |
| 摘要 目的：分析我院儿科患儿医院下呼吸道感染的病原菌分布情况和耐药性情况，为临床合理使用抗菌药物提供依据。方法：本文以我院儿科近年来（2015年8月至2016年8月期间）临床收治的下呼吸道感染患儿566例为研究对象，针对患儿的病原菌分布情况和耐药性情况进行了调查研究。结果：本次研究的566例患儿共检出病原菌126株，病原菌检出率为22.26%。其中肺炎克雷伯菌、大肠埃希氏菌、金黄色葡萄球菌和表皮葡萄球菌，构成比分别为23.80%、17.56%、10.32%和7.14%；肺炎克雷伯菌对氨苄西林、头抱曲松、复方新诺明、氨曲南的耐药率分别为76.67%、73.33%、36.67%和26.67%；大肠埃希氏菌对氨苄西林、复方新诺明、头抱曲松、哌拉西林、头孢吡肟、头孢他啶的耐药率分别为72.73%、72.73%、68.18%、45.46%、27.27%、22.72%；金黄色葡萄球菌对氨苄西林、红霉素、阿奇霉素、克林霉素、复方新诺明、庆大霉素的耐药率分别为100.00%、84.6%、84.6%、69.23%、53.85%和38.46%。结论：儿科医院呼吸道感染的病原菌以肺炎克雷伯菌、大肠埃希氏菌和金黄色葡萄球菌为主，且多重耐药菌感染增多，临床抗菌药选择的应根据药敏试验结果进行针对性的选择用药以提高临床治疗的有效性及合理性，减少耐药菌株产生。 |
| 英文摘要: |
| ABSTRACT Objective: To fully understand and master the distribution and drug resistance status of the pathogen of lower respira- tory infection in hospitalized children in Department of Pediatrics in our hospital, so as to provide basis for appropriate prescription of an- ti-biotic drugs clinically. Methods: 566 cases of respiratory tract infection in Department of Pediatrics in our hospital in recent years (from August 2015 to August 2016) were chosen as the research objects. The distribution of children against pathogens and drug resistance were investigated. Results: 126 pathogens were found in the 566 cases, and pathogen detection rate was 22.26%. The constituent ratio of Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis was 23.80%, 17.56%, 10.32% and 7.14%, respectively. The drug resistance rate of Klebsiella pneumoniae to ampicillin, cephalosporin ceftriaxone, complex force sulfamethoxazole and aztreonam was 76.67%, 73.33%, 36.67% and 26.67%, respectively. The drug resistance rate of Es- cherichia coli to ampicillin, complex force new sulfamethoxazole, cephalosporin ceftriaxone, piperacillin, cefepime and ceftazidime was 72.73%, 72.73%, 68.18%, 45.46%, 27.27% and 22.72%, respectively. The drug resistance rate of Staphylococcus aureus to ampicillin, erythromycin, azithromycin, clindamycin, complex force sulfamethoxazole and gentamicin was 100.00%, 84.6%, 84.6%, 69.23%, 53.85% and 38.46%, respectively. Conclusion: The pathogens in respiratory infection in hospitalized children mainly consist of Klebsiel- la pneumoniae, Escherichia coli and Staphylococcus aureus, with increased multiple drug resistant bacteria. The clinical antibiotic selec- tion should be based on drug susceptibility test results in order to improve the clinical effectiveness and rationality of treatment, and to re- duce the occurrence of resistant bacteria. |
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