| 吴健瑜,杨海淦,张子敬,卢蔚起,郝 蕾.瘿瘤消散汤联合左甲腺素钠片治疗结节性甲状腺肿的疗效观察[J].现代生物医学进展英文版,2017,17(13):2477-2480. |
| 瘿瘤消散汤联合左甲腺素钠片治疗结节性甲状腺肿的疗效观察 |
| Clinical Efficacy of Gallae Xiaosan Decoction Combined with Levothyroxine Sodium Tablet for Patients with Nodular Goiter |
| Received:October 16, 2016 Revised:October 30, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.13.020 |
| 中文关键词: 瘿瘤消散汤 左甲腺素钠片 结节性甲状腺肿 疗效 |
| 英文关键词: Gallae xiaosan decoction Levothyroxine sodium tablet Nodular goiter Efficacy |
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| 中文摘要: |
| 摘要 目的：探讨瘿瘤消散汤联合左甲腺素钠片治疗结节性甲状腺肿的临床疗效。方法：选择2013年7月到2016年2月在我院门诊治疗的120例结节性甲状腺肿患者，随机分为对照组和试验组，各60例。对照组患者给予左甲腺素钠片治疗，试验组患者给予瘿瘤消散汤联合左甲腺素钠片治疗，两组患者均治疗6个月。评价并比较两组患者临床疗效。测量并比较两组患者治疗前后甲状腺结节最大横截面积和最大直径，检测并比较两组患者治疗前后血清促甲状腺激素（TSH）、促甲状腺素受体抗体（TRAb）、游离三碘甲状腺原氨酸（FT3）及游离甲状腺素（FT4）水平。结果：试验组患者的总有效率为86.67%，明显高于对照组的66.67%（P<0.05）。治疗后，两组患者的甲状腺结节最大横截面积、最大直径均明显低于治疗前，并且试验组患者均明显低于对照组（P<0.05）。治疗后，两组患者血清TSH、TRAb及FT3水平均明显低于治疗前，并且试验组患者均明显低于对照组，差异均具有统计学意义（P<0.05）；两组患者血清FT4水平治疗前后均无明显变化（P>0.05）。结论：瘿瘤消散汤联合左甲腺素钠片治疗结节性甲状腺肿的临床疗效显著，能够明显缓解临床症状和体征，值得在临床上推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical efficacy of gallae xiaosan decoction combined with levothyroxine sodium tablet for patients with nodular goiter. Methods: A total of 120 patients with nodular goiter treated in our hospital from July 2013 to February 2016 were enrolled in this study. The subjects were divided into control group (n=60) and treatment group (n=60) randomly. The control group was treated with levothyroxine sodium tablet, the treatment group was treated with gallae xiaosan decoction combined with levothyroxine sodium tablet, the two groups were treated for 6 months. The clinical efficacy of the two groups were compared. The maximum cross-sectional area and the maximum diameter of thyroid nodules of the two groups before and after treatment were compared. The lev- els of serum thyroid stimulating hormone (TSH), thyroid stimulating hormone receptor antibodies(TRAb), free triiodothyronine (FT3) and free thyroxine (FT4) of the two groups before and after treatment were compared. Results: The total effective rate of the treatment group was 86.67%, significantly higher than 66.67% of the control group (P<0.05). The maximum cross-sectional area and the maximum diameter of thyroid nodules of the two groups after treatment were significantly lower than before treatment, and those of the treatment group were significantly lower than the control group (P<0.05). The levels of serum TSH, TRAb and FT3 of the two groups after treat- ment were significantly lower than before treatment, and those of the treatment group were significantly lower than the control group(P<0.05). There was no significantly difference of the levels of serum FT4 of the two groups before and after treatment (P>0.05). Conclusion: Gallae xiaosan decoction combined with levothyroxine sodium tablet for patients with nodular goiter have good clinical efficacy,which can significantly relieve the clinical symptoms and signs, it was worthy of clinical application. |
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