| 罗春生,宋 丽,王月香,席 燕,刘红阳,谢 岩.埃索美拉唑联合胃力康颗粒对胃食管反流的临床疗效及其对患者促甲状腺激素、胃蛋白酶原水平的影响[J].现代生物医学进展英文版,2017,17(13):2466-2469. |
| 埃索美拉唑联合胃力康颗粒对胃食管反流的临床疗效及其对患者促甲状腺激素、胃蛋白酶原水平的影响 |
| Effects of Esomeprazole Combined with Wilikang Granules on the Serum TSH and Pepsinogen Levels in Patients with Gastroesophageal Reflux and Its Clinical Efficacy |
| Received:October 15, 2016 Revised:November 03, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.13.017 |
| 中文关键词: 埃索美拉唑 胃力康颗粒 胃食管反流 促甲状腺激素(TSH) 胃蛋白酶原 |
| 英文关键词: Esomeprazole Weilikang granules Gastroesophageal reflux Thyroid stimulating hormone (TSH) Pepsinogen |
| 基金项目:新疆自治区自然科学基金项目(20090026) |
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| 中文摘要: |
| 摘要 目的：探讨埃索美拉唑联合胃力康颗粒对胃食管反流的临床疗效及其对患者促甲状腺激素、胃蛋白酶原水平的影响。方法：选取我院老年病科诊断为胃食管反流患者70例，按随机数字表法平均分为两组，对照组35例予以胃力康颗粒治疗，观察组35例在对症治疗基础上联合埃索美拉唑治疗，测定并记录两组治疗前后血清促甲状腺激素(TSH)、胃蛋白酶原(PG Ⅰ、Ⅱ)水平、反流症状评分，治疗后临床疗效及不良反应的发生情况。结果：观察组治疗有效率显著高于对照组，差异具有统计学意义(P＜0.05)。与对照组比较，观察组治疗后促甲状腺激素水平较高，PGⅠ水平较高，PGⅡ水平较低，反流症状评分水平较低，差异具有统计学意义(P＜0.05)。结论：埃索美拉唑联合胃力康颗粒治疗胃食管反流的临床效果显著，且能升高促甲状腺激素及PGⅠ水平，降低PGⅡ水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of esomeprazole combined with wilikang granules on serum levels of TSH and pepsinogen in patients with gastroesophageal reflux and its clinical efficacy. Methods: 70 patients with gastroesophageal reflux who were treated in our hospital were selected and randomly divided into two groups, with 35 cases in each group. The patients in the control group were treated with wilikang granules, while the patients in the experiment group were treated with esomeprazole on the basis of symp- tomatic treatment. Then the serum levels of thyroid stimulating hormone (TSH) and pepsinogen (PG I and PG II), and the reflux symp- toms score, the clinical efficacy and adverse reactions in the two groups were observed and compared. Results: The effective rate in the experiment group was higher than that of the control group, and the difference was statistically significant (P<0.05); Compared with the control group, the levels of thyroid stimulating hormone and PG I in the experiment group were higher, while the levels of PGⅡ and re- flux symptoms score were lower, and the differences were statistically significant (P<0.05). Conclusion: Esomeprazole combined with weilikang granules have better effects on the treatment of gastroesophageal reflux, which can increase the thyroid stimulating hormone and PG I levels, and reduce PG Ⅱ. |
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