Article Summary
刘 有,张晓欢,苗兰英,刘 鸿,白 剑.HLA-G在肿瘤组织中表达情况研究进展[J].现代生物医学进展英文版,2017,17(12):2397-2400.
HLA-G在肿瘤组织中表达情况研究进展
The Research Progress of HLA-G Expression on Tumor Tissues
Received:January 08, 2016  Revised:February 01, 2016
DOI:10.13241/j.cnki.pmb.2017.12.050
中文关键词: HLA-G  肿瘤组织  免疫  抑制  逃逸
英文关键词: HLA - G  Tumor tissue  Immune  Inhibition  Escape
基金项目:辽宁省自然科学基金项目(2015020714)
Author NameAffiliationE-mail
刘 有 解放军总医院海南分院 海南 三亚 572000 1634756467@qq.com 
张晓欢 解放军总医院海南分院 海南 三亚 572000  
苗兰英 辽宁中医药大学 辽宁 沈阳 110847  
刘 鸿 辽宁中医药大学 辽宁 沈阳 110847  
白 剑 辽宁中医药大学 辽宁 沈阳 110847中国人民解放军第三Ο九医院器官移植研究所 北京 100091  
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中文摘要:
      摘要:人类白细胞抗原G (human leukocyte antigen, HLA-G)属于非经典HLA-I类分子,在多种肿瘤细胞上均有表达。从结构上可以将HLA-G分为7种亚型:膜结合型HLA-G1-HLA-G4和可溶型HLA-G5-HLA-G7。研究表明,HLA-G1和HLA-G5具有明确的生物学活性也是研究较为深入的两种亚型,他们可以与T淋巴细胞、B淋巴细胞和NK细胞表面的ILT2/CD85j/LILRB1,ILT4/CD85d/LILRB2,KIR2DL4/CD158d受体结合而发挥免疫抑制功能。目前,HLA-G分子可以在肝癌、肾癌、肺癌、胃癌、食道癌、鼻咽癌、卵巢癌、乳腺癌、宫颈癌、直肠癌和血液肿瘤中表达。本文从HLA-G分子的结构和功能出发,综述了HLA-G分子在上述肿瘤中表达的情况,旨在分析HLA-G在各种肿瘤组织中表达的特点以及临床意义,为临床早期诊断和治疗肿瘤提供参考。
英文摘要:
      ABSTRACT: Human leukocyte antigen G (HLA-G), a nonclassical HLA class I molecule, is selectively expressed in many cancer cells. HLA-G encoding gene has limited polymorphisms. Structurally, there are seven isoforms that can be translated from HLA-G primary transcripts: HLA-G1 to HLA-G4 as membrane-bound proteins and HLA-G5 to HLA-G7 as soluble molecules. HLA-G1 and HLA-G5 molecules were the ones to be heavily involved in various physiological situations and, of course, mostly studied. They can bind ILT2/CD85j/LILRB1, ILT4/CD85d/LILRB2, and KIR2DL4/CD158d receptors located in the surface of T lymphocytes, B lymphocytes and NK cells, and perform immunosuppressive functions. To date, HLA-G can express on liver cancer, renal cancer, lung cancer,gastric cancer, esophagus cancer, nasopharynx cancer, ovarian cancer, breast cancer, cervical cancer, rectal cancer and leukemia. This article analyzed molecular structure and function of HLA-G, and reviewed expression of HLA-G on tumor cells. From analysis of characteristics of HLA G molecule expressed on some kinds of tumor tissue and its clinical significance, some reference for clinical early diagnosis and treatment of tumor was conducted.
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