| 彭 易,彭秀达,刘龙飞,卢先州,彭扬娥,李 峰,周筱筠.MicroRNA-203在结直肠癌研究中的进展[J].现代生物医学进展英文版,2017,17(12):2394-2396. |
| MicroRNA-203在结直肠癌研究中的进展 |
| Progress of MicroRNA-203 in Colorectal Cancer |
| Received:November 01, 2016 Revised:November 22, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.049 |
| 中文关键词: 结直肠癌 mircroRNA-203 靶蛋白 信号通路 耐药性 |
| 英文关键词: colorectal cancer MicroRNA-203 Target protein Signal pathways Drug resistance |
| 基金项目:湖南省卫生厅科研基金项目（B2013-049） |
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| 中文摘要: |
| 摘要：结直肠癌是我国常见的消化道恶性肿瘤。目前认为结直肠癌的形成是一个多因素、多步骤的过程，其具体发病机制尚不清楚。microRNA 是一类非编码小分子RNA，能在转录后水平调控靶基因的表达，参与肿瘤的增殖、侵袭和转移，甚至调节肿瘤化疗敏感性。学者普遍认为mircroRNA-203(mir-203)是抗癌小分子RNA，但与以往不同的是mir-203在结直肠癌肿的表达水平仍存在争议。本文将概述mir-203在结直肠癌的发生、发展、诊断、预后以及药物抗性中发挥的各类生物学作用。阐述mir-203在结直肠癌不同信号通路中的作用，探索其在结直肠癌研究中的全部潜能。 |
| 英文摘要: |
| ABSTRACT: Colorectal cancer is a common gastrointestinal malignancy in our country. It is accepted that the etiology of colorectal cancer is a multi-factor and multi-step process. However, the mechanism of CRC is still unclear. Micro-RNAs (miRNA) are short noncoding RNAs and function as a negative regulator of gene expression at post-transcriptional level, participating in tumor cell proliferation, invasion, migration and even drug resistance. It is accepted that mir-203 acts as a tumor suppressor. However, its expression in colon cancer is still a controversy. The implication of Mir-203 in various cellular biological activities including tumorigenesis, progression, diagnose, prognosis, chemoresistance will be summarized in this article With the purpose of better understanding of the role of microRNA-203 in gene network of colorectal cancer may help exploit the whole potential of mir-203 in coloretal cancer. |
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