| 李 娇,许 卓,赵 洋,蔡广研,张 利,陈香美.mTORC1在慢性肾功能不全胰岛素抵抗中的作用[J].现代生物医学进展英文版,2017,17(12):2390-2393. |
| mTORC1在慢性肾功能不全胰岛素抵抗中的作用 |
| Insulin Resistance and Altered mTORC1 Signaling Expression in Chronic Kidney Disease |
| Received:December 08, 2016 Revised:December 28, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.048 |
| 中文关键词: 慢性肾功能不全 胰岛素抵抗 mTORC1 信号转导通路 |
| 英文关键词: Chronic kidney disease Insulin resistance mTORC1 Signal transduction pathway |
| 基金项目:国家重点基础研究发展计划项目"973项目"(2015CB553605) |
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| 中文摘要: |
| 摘要：代谢综合征（MetS）在慢性肾功能不全（CKD）患者中普遍存在，与CKD预后密切相关。胰岛素抵抗（IR）作为MetS的基础，是非糖尿病CKD患者疾病进展的独立危险因素。而mTORC1信号通路可感受多种环境变化调节机体的生长代谢稳态，参与肿瘤、肥胖、2型糖尿病等多种疾病发生发展过程。mTORC1过度激活被认为是2型糖尿病IR的机制之一，但在CKD疾病状态下，mTORC1与IR的关系尚不十分清楚。本文就CKD疾病状下，mTORC1对胰岛素信号通路的影响，做一简要概述，为CKD患者IR的治疗提供参考。 |
| 英文摘要: |
| ABSTRACT: Metabolic syndrome （MetS） is associated with chronic kidney disease (CKD) development. Insulin resistance (IR) plays a central role in the MetS and is associated with increased risk for CKD in nondiabetic patients. The mammalian target of rapamycin complex 1 (mTORC1) pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, and type 2 diabetes. Overexpression of mTORC1 in type 2 diabetes is thought to be one of the mechanisms of IR. However, the role of mTORC1 on insulin signaling pathway in CKD is less clear. Here, we review the mTORC1 pathway under the condition of IR in CKD to provide help for the prognosis of CKD patients. |
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