| 朱 锋,王 旭,刘倩莹,陆启荣,黄德玉,刘振利,戴梦红,袁宗辉.表观遗传学及其研究方法[J].现代生物医学进展英文版,2017,17(12):2371-2376. |
| 表观遗传学及其研究方法 |
| Epigenetics and Its Research Methods |
| Received:July 13, 2016 Revised:August 05, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.044 |
| 中文关键词: 表观遗传学 DNA甲基化 组蛋白修饰 非编码RNA |
| 英文关键词: Epigenetics DNA methylation Histone modification Non-coding RNA |
| 基金项目:国家自然科学基金项目(31272614) |
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| 中文摘要: |
| 摘要：表观遗传学是一门重要的生命学科，主要包括DNA的甲基化、组蛋白修饰以及非编码RNA等内容，其中任何一方面的表观遗传学变化对生物体的生命过程都有重要的影响。近年来随着生命科学的快速发展，表观遗传学越来越受到人们的关注，各种先进科技的应用也使得表观遗传学实验技术得到快速的发展。本文对DNA甲基化、组蛋白修饰及非编码RNA的基本内容及实验方法进行了综述，并对不同的研究方法进行分析，有利于表观遗传学的深入研究。 |
| 英文摘要: |
| ABSTRACT: Epigenetics is an important discipline of life, mainly including DNA methylation, histone modification, non-coding RNA and some other changes. Any changes of epigenetics will have an important impact on the development of body. With the rapid development of life science, epigenetics has got more and more attention and epigenetics has a rapid development with the various applications of advanced technologies in recent years. Methods of experiment and the basic content of DNA methylation, histone modification and non-coding RNA are summarized, and different ways of study on epigenetics are analyzed in this paper. And it is good for the deep research of epigenetics. |
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