| 卢 宝,梁月竹,王春钢,赵桂梅,高淑英.心理治疗联合利培酮治疗精神分裂症的疗效及安全性[J].现代生物医学进展英文版,2017,17(12):2357-2360. |
| 心理治疗联合利培酮治疗精神分裂症的疗效及安全性 |
| Clinical Efficacy and Security of Psychotherapy Combined with Risperidone in the Treatment of Patients with Schizophrenia |
| Received:December 02, 2016 Revised:December 25, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.040 |
| 中文关键词: 精神分裂症 心理治疗 利培酮 安全性 |
| 英文关键词: Schizophrenia Psychotherapy Risperidone Security |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨心理治疗联合利培酮治疗精神分裂症的临床效果及安全性。方法：选取2013年7月至2015年7月在我院接受治疗的精神分裂症患者91例，随机分为对照组46例和观察组45例，对照组患者给予单纯利培酮片治疗，观察组在对照组的基础上给予患者心理治疗。观察比较治疗前后两组患者社会功能评定量表(SSPI)、功能评定量表(GAS)、日常生活能力量表(ADL)、蒙哥马利-艾斯伯格抑郁量表(MADRS)、简明精神症状评定量表(BPRS)及阳性与阴性症状量表(PANSS)的变化，以及两组的临床疗效。结果：治疗12个月后，两组的SSPI、GAS及ADL均有显著升高，且观察组明显高于对照组，比较差异有统计学意义(P＜0.05)。两组的MADRS、BPRS及PANSS均有显著降低，且观察组明显低于对照组，比较差异有统计学意义(P＜0.05)。观察组的临床总有效率为88.9%，显著高于对照组的71.7%，比较差异具有统计学意义(P＜0.05)。结论：心理治疗联合利培酮能显著改善精神分裂症患者的精神症状，提高患者的社会功能，临床疗效显著，且安全性好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy and security of psychotherapy combined with risperidone in the treatment of patients with schizophrenia. Methods: Ninety-one patients with schizophrenia admitted into our hospital were randomly divided into the control group and the observation group. Forty-six patients in the control group were treated with risperidone, and forty-five patients in the observation group were treated with psychotherapy combined with risperidone. The SSPI, GAS, ADL, MADRS, BPRS, and PANSS were observed and compared before and after treatment between the two groups, and the clinical efficacy was also compared after treatment. Results: After 12 months of treatment, the SSPI, GAS, and ADL scores in both groups were obviously improved(P＜0.05), which were much higher in the observation group than those of the control group (P＜0.05). And the MADRS, BPRS and PANSS scores of both groups showed remarkable decrease (P＜0.05), which were significantly lower in the observation group than those of the control group (P＜0.05). Additionally, the total effective was 88.9% in the observation group, which was conspicuously higher than that of control group (P＜0.05). Conclusion: Psychotherapy combined with risperidone had a great ability of improving the psychiatric symptoms and social function of patients with schizophrenia. |
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