| 刘兰兰,马雪平,宋 娜,张 翠,张 景.乳腺癌手术前后凝血纤溶功能及血小板参数变化及意义[J].现代生物医学进展英文版,2017,17(12):2321-2324. |
| 乳腺癌手术前后凝血纤溶功能及血小板参数变化及意义 |
| Variety and Value of Coagulation-fibrinolysis Function and Platelet Indexes before and after Surgery of Breast Cancer Patients |
| Received:August 28, 2016 Revised:September 22, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.030 |
| 中文关键词: 乳腺癌 凝血纤溶功能 血小板参数 手术 |
| 英文关键词: Breast cancer Coagulation-fibrinolysis function Platelet indexes Surgery |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨乳腺癌患者手术前后凝血纤溶功能及血小板参数的变化情况及其意义。方法：收取2014年2月至2016年2 月间于我院进行手术的乳腺癌患者90例作为研究对象进行回顾性分析，对其手术前一天及手术后凝血纤溶功能及血小板参数进行比较，另选择同期于我院进行体检的35例健康女性作为对照。结果：乳腺癌组手术前凝血纤溶功能各指标均显著高于对照组，手术后纤维蛋白原（FIB）、D-二聚体（D-D）均较术前明显升高，凝血酶原时间（PT）、活化部分凝血酶时间（APTT）明显降低，差异有统计学意义（P<0.05）。乳腺癌组手术前血小板参数均显著高于对照组，手术后血小板压积（PCT）、平均血小板体积（MPV）、血小板分布宽度（PDW）均较术前明显升高，差异有统计学意义（P<0.05）。肿瘤分期为Ⅰ~Ⅱ期的患者PT、APTT、FIB及D-D变化幅度均小于Ⅲ期患者；无淋巴结转移的患者TT、APTT变化幅度小于有淋巴结转移的患者；HER-2受体阴性患者D-D变化幅度小于HER-2受体阳性患者，差异有统计学意义（P<0.05）。肿瘤分期为Ⅰ~Ⅱ期的患者血小板计数（PLT）及MPV变化幅度小于Ⅲ期患者；HER-2受体阴性患者PLT及MPV变化幅度小于HER-2受体阳性患者，差异有统计学意义（P<0.05）。结论：乳腺癌患者凝血纤溶功能及血小板参数均较健康女性有较大改变，且术后患者血液高凝状态更加明显，机体存在更高的血栓风险，应加强围手术期管理。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the variety and value of coagulation-fibrinolysis function and platelet indexes before and after surgery of breast cancer patients. Methods: 90 breast cancer patients accepted in our hospital from February 2014 to February 2016 were retrospectively analyzed. The coagulation-fibrinolysis function and platelet indexes one day before surgery and after surgery were compared. And 35 healthy female underwent physical examination were selected as control. Results: The coagulation-fibrinolysis function of breast cancer group before surgery was obviously higher than that of control group. The expression levels of FIB, D-D after surgery were obviously higher than before, and PT, APTT were obviously lower than before with statistically significance (P<0.05). The platelet indexes of breast cancer group were obviously higher than that of control group, and the expression levels of PCT, MPV and PDW were all higher than before with statistically significance (P<0.05). The variety of PT, APTT, FIB and D-D of stage Ⅰ~Ⅱ breast cancer patients were less than stage Ⅲ. The variety of TT and APTT of patients without lymph node metastasis were less than patients with lymph node metastasis. The variety of D-D of patients with HER-2 negative was less than patients with HER-2 positive. The differences above had statistically significance (P<0.05). The variety of PLT and MPV of stage Ⅰ~Ⅱ breast cancer patients were less than stage Ⅲ. The variety of PLT and MPV of patients with HER-2 negative was less than patients with HER-2 positive. The differences above had statistically significance (P<0.05). Conclusion: The coagulation-fibrinolysis function and platelet indexes of breast cancer patients has great change with hypercoagulation after surgery compared to healthy female, which can improve the risk of thrombosis. It is very important to strengthen the management in the perioperative period. |
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