| 冯 颖,郭 莉,谢一敦,王苏萍,安应飞.碱性成纤维细胞生长因子对下颌阻生牙手术患者血清IL-6水平及牙槽骨密度的影响[J].现代生物医学进展英文版,2017,17(12):2314-2316. |
| 碱性成纤维细胞生长因子对下颌阻生牙手术患者血清IL-6水平及牙槽骨密度的影响 |
| The Preventive Effect of Basic Fibroblast Growth Factor on the Serum IL-6 Level and Density of Alveolar Bone of Patients Underwent Mandibular Impacted Teeth Extraction |
| Received:October 17, 2016 Revised:November 13, 2016 |
| DOI：10.13241/j.cnki.pmb.2017.12.028 |
| 中文关键词: 碱性成纤维细胞生长因子 下颌阻生牙 牙槽骨密度 白细胞介素-6 感染 |
| 英文关键词: Fibroblast growth factor Tooth extraction Infection |
| 基金项目:陕西省自然科学基金项目(7990331) |
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| 中文摘要: |
| 摘要 目的：探讨碱性成纤维细胞生长因子对对下颌阻生牙手术患者血清IL-6水平及牙槽骨密度的影响。方法：收集我院就诊的104例行下颌阻生牙手术患者，随机分为实验组和对照组，每组52例。所有患者均行下颌阻生牙手术。对照组患者术后注射生理盐水，实验组患者术后注射碱性成纤维细胞生长因子。观察并比较两组患者血清白介素6(IL-6)、牙槽骨密度水平、临床治疗有效率以及不良反应发生情况。结果：与治疗前相比，两组患者治疗后的骨密度水平均升高，IL-6水平均下降，差异具有统计学意义(P<0.05)；与对照组相比，实验组患者的牙槽骨密度水平及临床治疗有效率均较高，IL-6水平较低，差异具有统计学意义(P<0.05)。实验组患者未出现不良明显反应。结论：碱性成纤维细胞生长因子可显著提高下颌阻生牙术后患者的创口恢复，且有效预防感染的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the preventive effect of basic fibroblast growth factor on the serum il-6 level and density of alveolar bone of patients underwent mandibular impacted teeth extraction. Methods: 104 cases of patients with mandibular impacted tooth extraction were randomly divided into the experimental group and the control group with 52 cases in each group. All patients underwent mandibular impacted tooth operation. Patients in the control group were treated with normal saline injection after operation, while patients in the experimental group were treated with basic fibroblast growth factor injection after operation. Then the serum levels of interleukin 6 (IL-6) and alveolar bone density, the clinical effective rate and the adverse reactions in the two groups were observed and compared. Results: Compared with before treatment, the serum levels of bone mineral density in the two groups increased, while the serum levels of IL-6 decreased after the treatment(P<0.05); Compared with the control group, the levels of bone mineral density in the experimental group were higher, and the serum levels of IL-6 were lower after the treatment(P<0.05); Compared with the control group, the clinical effective rate in the experimental group was higher(P<0.05); There was no obvious adverse reactions after the treatment in the two groups(P>0.05). Conclusion: Basic fibroblast growth factor could significantly promote the recovery of patients after mandibular impacted tooth extraction and effectively prevent the infections. |
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