| 杜 辉,张文文,牛君义,宋 威,陈凤英.川芎嗪注射液对冠心病心绞痛患者临床症状及血液流变学的影响[J].现代生物医学进展英文版,2017,17(12):2298-2301. |
| 川芎嗪注射液对冠心病心绞痛患者临床症状及血液流变学的影响 |
| Influence of Ligustrazine Injection on Clinical Symptoms and Hemorheology in Patients With Coronary Heart Disease and Angina Pectoris |
| Received:December 26, 2016 Revised:January 20, 2017 |
| DOI：10.13241/j.cnki.pmb.2017.12.024 |
| 中文关键词: 冠心病 心绞痛 川芎嗪注射液 血液流变学 |
| 英文关键词: Coronary heart disease Angina pectoris Ligustrazine injection Hemorheology |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：探讨川芎嗪注射液对冠心病（CHD）心绞痛患者临床症状及血液流变学的影响。方法：选择2014年3月至2016年3月在我院进行治疗的CHD心绞痛患者60例，按随机数字表法分为实验组和对照组各30例，对照组患者给予常规治疗，实验组患者在常规治疗基础上加用川芎嗪注射液治疗，两组患者均治疗20 d，比较两组患者临床疗效及治疗前后心绞痛症状、血液流变学指标和血脂指标。结果：实验组治疗后的总有效率高于对照组（P<0.05）。两组治疗后心绞痛发作次数、发作时长均减少，且实验组少于对照组（P<0.05）。治疗后，两组的全血黏度、血浆黏度、红细胞聚集指数、纤维蛋白原（Fib）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）均低于治疗前，且实验组低于对照组，（P＜0.05）。结论：川芎嗪在治疗CHD心绞痛方面具有显著的疗效，不仅能够有效改善患者心绞痛症状，还能改善血液流变学异常情况，因此值得临床推广使用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the influence of ligustrazine injection on clinical symptoms and hemorheology in patients with coronary heart disease(CHD) and angina pectoris. Methods: 60 patients with CHD and angina pectoris who were treated in our hospital from March 2014 to March 2016 were selected, and they were divided into study group and control group with 30 cases in each group.The control group were treated conventional treatment, while the study group were treated ligustrazine injection on the basis of routine treatment.Two groups were treated for 20 days, and the clinical efficacy, angina symptoms,hemorheology index and blood lipid index of the two groups were compared before and after treatment. Results: The total effective rate of study group was higher than control group after treatment(P<0.05). The angina attack frequency and duration in two groups were significantly lowered after treatment, and the study group was significantly lower than that of the control group(P<0.05). The levels of whole blood viscosity, plasma viscosity, erythrocyte aggregation index, fibrinogen(Fib), total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C)in two groups after treatment were lower than before treatment, and the study group was lower than the control group(P<0.05). Conclusion: Ligustrazine has significant curative effect in treatment of CHD and angina pectoris,which not olny can effectively improve the angina pectoris symptoms,but also improve hemorheology abnormal situation, therefore, it is worth promotion and application in clinic. |
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